AJP - Heart and Circulatory Physiology, Vol 266, Issue 6 2296-H2302, Copyright © 1994 by American Physiological Society

ARTICLES

Influence of heart rate and left atrial pressure on pulmonary venous flow pattern in dogs

T. Steen, B. M. Voss and O. A. Smiseth
Institute for Surgical Research, Rikshospitalet, University of Oslo, Norway.

In six open-chest anesthetized dogs we investigated the effect of heart rate (HR) on the relationship between left atrial pressure (LAP) and pulmonary venous flow (QPV). QPV was measured by ultrasonic transit time during volume loading and right atrial pacing. Consistent with previous studies, we found a negative correlation between LAP and mean flow rate during atrial systole divided by mean flow rate in the R-R interval. However, this relationship was shifted upward by tachycardia. The QPV maximum amplitude divided by mean flow rate in the R-R interval increased with loading but decreased with tachycardia. mean flow rate during ventricular systole divided by mean flow rate during the R-R interval increased with both loading and tachycardia. Regression coefficients for HR and LAP as predictors of these indexes were all significantly different from zero (P = 0.0001). We conclude that HR significantly influences the relationship between the QPV pattern and LAP. This could be a limitation of the pulmonary venous flow pattern as an indicator of left ventricular diastolic function.

This article has been cited by other articles:

				J. O. Hunderi, C. R. Thompson, and O. A. Smiseth Deceleration time of systolic pulmonary venous flow: a new clinical marker of left atrial pressure and compliance J Appl Physiol, February 1, 2006; 100(2): 685 - 689. [Abstract] [Full Text] [PDF]

				S F de Marchi, M Bodenmüller, D L Lai, and C Seiler Pulmonary venous flow velocity patterns in 404 individuals without cardiovascular disease Heart, January 1, 2001; 85(1): 23 - 29. [Abstract] [Full Text]