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Am J Physiol Heart Circ Physiol 267: H962-H969, 1994;
0363-6135/94 $5.00
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AJP - Heart and Circulatory Physiology, Vol 267, Issue 3 962-H969, Copyright © 1994 by American Physiological Society

ARTICLES

Cooling and pH jump-induced calcium release from isolated cardiac sarcoplasmic reticulum

J. J. Feher and I. M. Rebeyka
Department of Physiology, Medical College of Virginia, Richmond 23298.

Rapid-cooling contracture in cardiac muscle preparations is thought to be caused by the release of Ca2+ from the sarcoplasmic reticulum (SR), but the mechanism of this release is unknown. Cooling of isolated canine cardiac SR from 37 to 4 degrees C resulted in the net release of enough Ca2+ to account for rapid-cooling contracture. The release of Ca2+ on cooling appeared to be a relaxation between different steady-state levels of Ca2+ uptake. Cooling release of Ca2+ was also observed in the presence of ryanodine or ruthenium red to block the ryanodine-sensitive Ca2+ efflux pathway. In the presence of ryanodine, the extent and initial rate of rapid-cooling release were increased due to increased steady-state uptake of Ca2+ by the SR. The first-order rate constant of rapid-cooling Ca2+ release was unchanged by ryanodine or ruthenium red, suggesting that the rapid-cooling release does not occur through the ryanodine-sensitive pathway. The alkalinization on cooling was not the major cause of the Ca2+ release, as comparable Ca2+ release was observed with cooling and no alkalinization. However, alkalinization without cooling produced a rapid net Ca2+ release, which was also observed in the presence of ryanodine.


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