AJP - Heart Calcium Transients and Cell-Sarcomere
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Heart Circ Physiol 268: H1422-H1427, 1995;
0363-6135/95 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Tod, M. L.
Right arrow Articles by Gordon, J. B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Tod, M. L.
Right arrow Articles by Gordon, J. B.

AJP - Heart and Circulatory Physiology, Vol 268, Issue 4 1422-H1427, Copyright © 1995 by American Physiological Society

ARTICLES

Sites of inhaled NO-induced vasodilation during hypoxia and U-46619 infusion in isolated lamb lungs

M. L. Tod, D. C. O'Donnel and J. B. Gordon
Department of Medicine, University of Maryland School of Medicine, Baltimore 21201, USA.

The sites of relaxation in response to inhaled nitric oxide (NO) were investigated using the vascular occlusion technique in isolated blood-perfused lungs from 1- to 3-mo-old lambs. In one group of 10 lungs, inhaled NO (45 ppm) was administered during hypoxia- and U-46619-induced pulmonary vasoconstriction. In a second group of 5 lungs, responses to inhaled NO and infused sodium nitroprusside (SNP, 3 micrograms.kg-1.min-1) during U-46619-induced hypertension were compared. Hypoxia caused significant pulmonary vasoconstriction, with increases in the pressure gradients of large and small arteries and small veins, as defined by vascular occlusion. Inhaled NO significantly reduced the total pulmonary pressure gradient by 67% and relaxed both large and small arteries. Infusion of U-46619 caused significant increases in all segmental pressure gradients. While inhaled NO was effective in relaxing the large and small arteries and the small veins, it had no effect on the large veins. Infusions of SNP, a nitrosovasodilator thought to act like endogenous NO, caused a similar degree of total relaxation as NO (81 vs. 77%, respectively). However, in contrast to inhaled NO, SNP was effective in reducing the pressure gradient of the large pulmonary veins. These results suggest that rapid binding to and thus inactivation of inhaled NO by hemoglobin limit its efficacy as a pulmonary venous dilator.


This article has been cited by other articles:


Home page
 Am. J. Respir. Crit. Care Med.Home page
L. J. BJERTNAES, T. KOIZUMI, and J. H. NEWMAN
Inhaled Nitric Oxide Reduces Lung Fluid Filtration after Endotoxin in Awake Sheep
Am. J. Respir. Crit. Care Med., November 1, 1998; 158(5): 1416 - 1423.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
S. C. Hillier, J. A. Graham, C. C. Hanger, P. S. Godbey, R. W. Glenny, and W. W. Wagner Jr.
Hypoxic vasoconstriction in pulmonary arterioles and venules
J Appl Physiol, April 1, 1997; 82(4): 1084 - 1090.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online