AJP - Heart AJP: Cell Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Heart Circ Physiol 269: H550-H555, 1995;
0363-6135/95 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Ranjan, V.
Right arrow Articles by Diamond, S. L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ranjan, V.
Right arrow Articles by Diamond, S. L.

AJP - Heart and Circulatory Physiology, Vol 269, Issue 2 550-H555, Copyright © 1995 by American Physiological Society

ARTICLES

Constitutive NOS expression in cultured endothelial cells is elevated by fluid shear stress

V. Ranjan, Z. Xiao and S. L. Diamond
Department of Chemical Engineering, State University of New York, Buffalo 14260, USA.

The role of chronic fluid shear stress on endothelial constitutive nitric oxide synthase (cNOS) levels may have an important role in vessel diameter control. We subjected primary human umbilical vein endothelial cells (HUVEC) or bovine aortic endothelial cells (BAEC, passages 2-14) to steady laminar shear stress. In both cell types, the intracellular level of cNOS was elevated within 3 h of flow exposure at 25 dyn/cm2 and remained elevated at 6 and 12 h of flow exposure, compared with stationary controls, as indicated by digital immunofluorescence microscopy. Shear stress exposure for 6 h caused a 2.2 +/- 0.3- and 2.8 +/- 0.3-fold elevation of cNOS protein levels in BAEC (n = 3, P < 0.01) and HUVEC (n = 3, P < 0.01), respectively, in the presence or absence of 1 microM dexamethasone. Dexamethasone suppresses induction of the inducible NOS gene, indicating that cNOS was elevated by fluid shear stress. Flow exposure at 4 dyn/cm2 caused no enhancement of cNOS levels in either cell type. The flow induction of the cNOS protein levels was not blocked by preincubation of BAEC with 100-400 microM of NG-nitro-L-arginine methyl ester, indicating that flow-induced NO (or guanosine 3',5'-cyclic monophosphate) was not involved in the elevation of cNOS levels. Protein kinase C inhibitor H-7 (10 microM) had no effect on induction of NOS protein in BAEC exposed to 25 dyn/cm2. The cNOS mRNA levels were found to be elevated by two- to threefold in BAEC after 6 or 12 h of flow exposure at either 4 or 25 dyn/cm2, and this induction of NOS mRNA occurred in the presence of dexamethasone. The elevation of cNOS levels by chronic flow exposure may provide a mechanism for chronic regulation of vessel diameter by endothelial response to prevailing blood flow.


This article has been cited by other articles:


Home page
 Physiol. Rev.Home page
J.-L. Balligand, O. Feron, and C. Dessy
eNOS Activation by Physical Forces: From Short-Term Regulation of Contraction to Chronic Remodeling of Cardiovascular Tissues
Physiol Rev, April 1, 2009; 89(2): 481 - 534.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
N. Sud, S. Kumar, S. Wedgwood, and S. M. Black
Modulation of PKC{delta} signaling alters the shear stress-mediated increases in endothelial nitric oxide synthase transcription: role of STAT3
Am J Physiol Lung Cell Mol Physiol, March 1, 2009; 296(3): L519 - L526.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
E. Metaxa, H. Meng, S. R. Kaluvala, M. P. Szymanski, R. A. Paluch, and J. Kolega
Nitric oxide-dependent stimulation of endothelial cell proliferation by sustained high flow
Am J Physiol Heart Circ Physiol, August 1, 2008; 295(2): H736 - H742.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
O. Yalcin, P. Ulker, U. Yavuzer, H. J. Meiselman, and O. K. Baskurt
Nitric oxide generation by endothelial cells exposed to shear stress in glass tubes perfused with red blood cell suspensions: role of aggregation
Am J Physiol Heart Circ Physiol, May 1, 2008; 294(5): H2098 - H2105.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
M. H. Laughlin, S. C. Newcomer, and S. B. Bender
Importance of hemodynamic forces as signals for exercise-induced changes in endothelial cell phenotype
J Appl Physiol, March 1, 2008; 104(3): 588 - 600.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
L. G. Chicoine, M. L. Paffett, M. R. Girton, M. J. Metropoulus, M. S. Joshi, J. A. Bauer, L. D. Nelin, T. C. Resta, and B. R. Walker
Maturational changes in the regulation of pulmonary vascular tone by nitric oxide in neonatal rats
Am J Physiol Lung Cell Mol Physiol, November 1, 2007; 293(5): L1261 - L1270.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
W. G. Hundley, E. Bayram, C. A. Hamilton, E. A. Hamilton, T. M. Morgan, S. N. Darty, K. P. Stewart, K. M. Link, D. M. Herrington, and D. W. Kitzman
Leg flow-mediated arterial dilation in elderly patients with heart failure and normal left ventricular ejection fraction
Am J Physiol Heart Circ Physiol, March 1, 2007; 292(3): H1427 - H1434.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
P. T. Nowicki
IL-1beta alters hemodynamics in newborn intestine: role of endothelin
Am J Physiol Gastrointest Liver Physiol, September 1, 2006; 291(3): G404 - G413.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
I. A. Arenas, Y. Xu, and S. T. Davidge
Age-associated impairment in vasorelaxation to fluid shear stress in the female vasculature is improved by TNF-{alpha} antagonism
Am J Physiol Heart Circ Physiol, March 1, 2006; 290(3): H1259 - H1263.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
R. C. Brunken, J. K. Perloff, J. Czernin, R. Campisi, S. Purcell, P. D. Miner, J. S. Child, and H. R. Schelbert
Myocardial perfusion reserve in adults with cyanotic congenital heart disease
Am J Physiol Heart Circ Physiol, November 1, 2005; 289(5): H1798 - H1806.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
C. R. Woodman, E. M. Price, and M. H. Laughlin
Shear stress induces eNOS mRNA expression and improves endothelium-dependent dilation in senescent soleus muscle feed arteries
J Appl Physiol, March 1, 2005; 98(3): 940 - 946.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
O. K. Baskurt, O. Yalcin, S. Ozdem, J. K. Armstrong, and H. J. Meiselman
Modulation of endothelial nitric oxide synthase expression by red blood cell aggregation
Am J Physiol Heart Circ Physiol, January 1, 2004; 286(1): H222 - H229.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
S. Mohan, M. Hamuro, G. P. Sorescu, K. Koyoma, E. A. Sprague, H. Jo, A. J. Valente, T. J. Prihoda, and M. Natarajan
Ikappa Balpha -dependent regulation of low-shear flow-induced NF-kappa B activity: role of nitric oxide
Am J Physiol Cell Physiol, April 1, 2003; 284(4): C1039 - C1047.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
S. Wedgwood, C. J. Mitchell, J. R. Fineman, and S. M. Black
Developmental differences in the shear stress-induced expression of endothelial NO synthase: changing role of AP-1
Am J Physiol Lung Cell Mol Physiol, April 1, 2003; 284(4): L650 - L662.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. GenomicsHome page
S. M. Wasserman, F. Mehraban, L. G. Komuves, R.-B. Yang, J. E. Tomlinson, Y. Zhang, F. Spriggs, and J. N. Topper
Gene expression profile of human endothelial cells exposed to sustained fluid shear stress
Physiol Genomics, December 26, 2002; 12(1): 13 - 23.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
C. R. Woodman, E. M. Price, and M. H. Laughlin
Aging induces muscle-specific impairment of endothelium-dependent dilation in skeletal muscle feed arteries
J Appl Physiol, November 1, 2002; 93(5): 1685 - 1690.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
L. G. Chicoine, J. W. Avitia, C. Deen, L. D. Nelin, S. Earley, and B. R. Walker
Developmental differences in pulmonary eNOS expression in response to chronic hypoxia in the rat
J Appl Physiol, July 1, 2002; 93(1): 311 - 318.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
G. Dai, O. Tsukurov, M. Chen, J. P. Gertler, and R. D. Kamm
Endothelial nitric oxide production during in vitro simulation of external limb compression
Am J Physiol Heart Circ Physiol, June 1, 2002; 282(6): H2066 - H2075.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
C. R. Woodman, W. G. Schrage, J. W. E. Rush, C. A. Ray, E. M. Price, E. M. Hasser, and M. H. Laughlin
Hindlimb unweighting decreases endothelium-dependent dilation and eNOS expression in soleus not gastrocnemius
J Appl Physiol, September 1, 2001; 91(3): 1091 - 1098.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
S. Wedgwood, J. M. Bekker, and S. M. Black
Shear stress regulation of endothelial NOS in fetal pulmonary arterial endothelial cells involves PKC
Am J Physiol Lung Cell Mol Physiol, August 1, 2001; 281(2): L490 - L498.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
S. M. McCormick, S. G. Eskin, L. V. McIntire, C. L. Teng, C.-M. Lu, C. G. Russell, and K. K. Chittur
DNA microarray reveals changes in gene expression of shear stressed human umbilical vein endothelial cells
PNAS, July 31, 2001; 98(16): 8955 - 8960.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
M. H. Laughlin, J. S. Pollock, J. F. Amann, M. L. Hollis, C. R. Woodman, and E. M. Price
Training induces nonuniform increases in eNOS content along the coronary arterial tree
J Appl Physiol, February 1, 2001; 90(2): 501 - 510.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
D. Xiao, I. M. Bird, R. R. Magness, L. D. Longo, and L. Zhang
Upregulation of eNOS in pregnant ovine uterine arteries by chronic hypoxia
Am J Physiol Heart Circ Physiol, February 1, 2001; 280(2): H812 - H820.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
S. J. Zieman, G. Gerstenblith, E. G. Lakatta, G. O. Rosas, K. Vandegaer, K. M. Ricker, and J. M. Hare
Upregulation of the Nitric Oxide-cGMP Pathway in Aged Myocardium : Physiological Response to l-Arginine
Circ. Res., January 19, 2001; 88(1): 97 - 102.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
S. Gielen, G. Schuler, and R. Hambrecht
Exercise Training in Coronary Artery Disease and Coronary Vasomotion
Circulation, January 2, 2001; 103 (1): e1 - e6.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
R Schulz, D Schmidt, A Blum, X Lopes-Ribeiro, C Lücke, K Mayer, H Olschewski, W Seeger, and F Grimminger
Decreased plasma levels of nitric oxide derivatives in obstructive sleep apnoea: response to CPAP therapy
Thorax, December 1, 2000; 55(12): 1046 - 1051.
[Abstract] [Full Text]

Home page
 Circ. Res.Home page
S. A. Fisher, B. L. Langille, and D. Srivastava
Apoptosis During Cardiovascular Development
Circ. Res., November 10, 2000; 87(10): 856 - 864.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
J. W. E. Rush, M. H. Laughlin, C. R. Woodman, and E. M. Price
SOD-1 expression in pig coronary arterioles is increased by exercise training
Am J Physiol Heart Circ Physiol, November 1, 2000; 279(5): H2068 - H2076.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
B. R. Walker, T. C. Resta, and L. D. Nelin
Nitric oxide-dependent pulmonary vasodilation in polycythemic rats
Am J Physiol Heart Circ Physiol, November 1, 2000; 279(5): H2382 - H2389.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
C. C. Dos Santos and A. S. Slutsky
Cellular Responses to Mechanical Stress: Invited Review: Mechanisms of ventilator-induced lung injury: a perspective
J Appl Physiol, October 1, 2000; 89(4): 1645 - 1655.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
V. Hampl and J. Herget
Role of Nitric Oxide in the Pathogenesis of Chronic Pulmonary Hypertension
Physiol Rev, October 1, 2000; 80(4): 1337 - 1372.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
R. Tatchum-Talom, R. Schulz, J. R. McNeill, and F. H. Khadour
Upregulation of neuronal nitric oxide synthase in skeletal muscle by swim training
Am J Physiol Heart Circ Physiol, October 1, 2000; 279(4): H1757 - H1766.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
H. T. Yang, M. H. Laughlin, and R. L. Terjung
Prior exercise training increases collateral-dependent blood flow in rats after acute femoral artery occlusion
Am J Physiol Heart Circ Physiol, October 1, 2000; 279(4): H1890 - H1897.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
H. Ueno, P. Kanellakis, A. Agrotis, and A. Bobik
Blood Flow Regulates the Development of Vascular Hypertrophy, Smooth Muscle Cell Proliferation, and Endothelial Cell Nitric Oxide Synthase in Hypertension
Hypertension, July 1, 2000; 36(1): 89 - 96.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
M. Liu, L. Tremblay, S. D. Cassivi, X.-H. Bai, E. Mourgeon, A. F. Pierre, A. S. Slutsky, M. Post, and S. Keshavjee
Alterations of nitric oxide synthase expression and activity during rat lung transplantation
Am J Physiol Lung Cell Mol Physiol, May 1, 2000; 278(5): L1071 - L1081.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. GenomicsHome page
P. V. GUILLOT, L. LIU, J. A. KUIVENHOVEN, J. GUAN, R. D. ROSENBERG, and W. C. AIRD
Targeting of human eNOS promoter to the Hprt locus of mice leads to tissue-restricted transgene expression
Physiol Genomics, March 13, 2000; 2(2): 77 - 83.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
J. Navarro-Antolin, J. Rey-Campos, and S. Lamas
Transcriptional Induction of Endothelial Nitric Oxide Gene by Cyclosporine A. A ROLE FOR ACTIVATOR PROTEIN-1
J. Biol. Chem., February 4, 2000; 275(5): 3075 - 3080.
[Abstract] [Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
Y. S. Chang, J. A. Yaccino, S. Lakshminarayanan, J. A. Frangos, and J. M. Tarbell
Shear-Induced Increase in Hydraulic Conductivity in Endothelial Cells Is Mediated by a Nitric Oxide-Dependent Mechanism
Arterioscler Thromb Vasc Biol, January 1, 2000; 20(1): 35 - 42.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
S. Y. Chin, K. N. Pandey, S.-J. Shi, H. Kobori, C. Moreno, and L. G. Navar
Increased activity and expression of Ca2+-dependent NOS in renal cortex of ANG II-infused hypertensive rats
Am J Physiol Renal Physiol, November 1, 1999; 277(5): F797 - F804.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
M. Liu, A. K. Tanswell, and M. Post
Mechanical force-induced signal transduction in lung cells
Am J Physiol Lung Cell Mol Physiol, October 1, 1999; 277(4): L667 - L683.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
J. J. Chiu, B. S. Wung, H. J. Hsieh, L. W. Lo, and D. L. Wang
Nitric Oxide Regulates Shear Stress–Induced Early Growth Response-1 : Expression via the Extracellular Signal–Regulated Kinase Pathway in Endothelial Cells
Circ. Res., August 6, 1999; 85(3): 238 - 246.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
D. O. C. Anumba, S. C. Robson, R. J. Boys, and G. A. Ford
Nitric oxide activity in the peripheral vasculature during normotensive and preeclamptic pregnancy
Am J Physiol Heart Circ Physiol, August 1, 1999; 277(2): H848 - H854.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
A. Ichihara, H. Suzuki, Y. Miyashita, M. Naitoh, M. Hayashi, and T. Saruta
Transmural pressure inhibits prorenin processing in juxtaglomerular cell
Am J Physiol Regulatory Integrative Comp Physiol, July 1, 1999; 277(1): R220 - R228.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
T. Gloe, S. Riedmayr, H.-Y. Sohn, and U. Pohl
The 67-kDa Laminin-binding Protein Is Involved in Shear Stress-dependent Endothelial Nitric-oxide Synthase Expression
J. Biol. Chem., June 4, 1999; 274(23): 15996 - 16002.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
R. J. Hendrickson, P. A. Cahill, J. V. Sitzmann, and E. M. Redmond
Ethanol Enhances Basal and Flow-Stimulated Nitric Oxide Synthase Activity In Vitro by Activating an Inhibitory Guanine Nucleotide Binding Protein
J. Pharmacol. Exp. Ther., June 1, 1999; 289(3): 1293 - 1300.
[Abstract] [Full Text]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
P. T. Nowicki
Effects of sustained low-flow perfusion on the response to vasoconstrictor agents in postnatal intestine
Am J Physiol Gastrointest Liver Physiol, June 1, 1999; 276(6): G1408 - G1416.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
T. Watanabe, Y. Sakata, T. Fujioka, D. Sadamitsu, and T. Maekawa
Glucocorticoid Enhances Interleukin-1-Induced Pressor Response in Freely Moving Rats Through Its Effect on Nitric Oxide Release
J. Pharmacol. Exp. Ther., April 1, 1999; 289(1): 24 - 30.
[Abstract] [Full Text]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
R. Wiest, V. Shah, W. C. Sessa, and R. J. Groszmann
NO overproduction by eNOS precedes hyperdynamic splanchnic circulation in portal hypertensive rats
Am J Physiol Gastrointest Liver Physiol, April 1, 1999; 276(4): G1043 - G1051.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
S. C. Jones, C. R. Radinsky, A. J. Furlan, D. Chyatte, and A. D. Perez-Trepichio
Cortical NOS inhibition raises the lower limit of cerebral blood flow-arterial pressure autoregulation
Am J Physiol Heart Circ Physiol, April 1, 1999; 276(4): H1253 - H1262.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
C. R. Woodman, J. M. Muller, J. W. E. Rush, M. H. Laughlin, and E. M. Price
Flow regulation of ecNOS and Cu/Zn SOD mRNA expression in porcine coronary arterioles
Am J Physiol Heart Circ Physiol, March 1, 1999; 276(3): H1058 - H1063.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
M. Parviz, M. Bousamra II, J. H. Chammas, E. K. Birks, K. W. Presberg, E. R. Jacobs, and L. D. Nelin
Effects of chronic pulmonary overcirculation on pulmonary vasomotor tone
Ann. Thorac. Surg., February 1, 1999; 67(2): 522 - 527.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
R. C. Tyler, M. Muramatsu, S. H. Abman, T. J. Stelzner, D. M. Rodman, K. D. Bloch, and I. F. McMurtry
Variable expression of endothelial NO synthase in three forms of rat pulmonary hypertension
Am J Physiol Lung Cell Mol Physiol, February 1, 1999; 276(2): L297 - L303.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
T. C. Resta, L. G. Chicoine, J. L. Omdahl, and B. R. Walker
Maintained upregulation of pulmonary eNOS gene and protein expression during recovery from chronic hypoxia
Am J Physiol Heart Circ Physiol, February 1, 1999; 276(2): H699 - H708.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
F. Karantzoulis-Fegaras, H. Antoniou, S.-L. M. Lai, G. Kulkarni, C. D'Abreo, G. K. T. Wong, T. L. Miller, Y. Chan, J. Atkins, Y. Wang, et al.
Characterization of the Human Endothelial Nitric-oxide Synthase Promoter
J. Biol. Chem., January 29, 1999; 274(5): 3076 - 3093.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
M. R. Cernadas, L. S. de Miguel, M. Garcia-Duran, F. Gonzalez-Fernandez, I. Millas, M. Monton, J. Rodrigo, L. Rico, P. Fernandez, T. de Frutos, et al.
Expression of Constitutive and Inducible Nitric Oxide Synthases in the Vascular Wall of Young and Aging Rats
Circ. Res., August 10, 1998; 83(3): 279 - 286.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
K. Yamamoto, Q. N. Dang, R. A. Kelly, and R. T. Lee
Mechanical Strain Suppresses Inducible Nitric-oxide Synthase in Cardiac Myocytes
J. Biol. Chem., May 8, 1998; 273(19): 11862 - 11866.
[Abstract] [Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
T. Ziegler, K. Bouzourene, V. J. Harrison, H. R. Brunner, and D. Hayoz
Influence of Oscillatory and Unidirectional Flow Environments on the Expression of Endothelin and Nitric Oxide Synthase in Cultured Endothelial Cells
Arterioscler Thromb Vasc Biol, May 1, 1998; 18(5): 686 - 692.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
N. R. Harris and K. W. Langlois
Age-dependent responses of the mesenteric vasculature to ischemia-reperfusion
Am J Physiol Heart Circ Physiol, May 1, 1998; 274(5): H1509 - H1515.
[Abstract] [Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
B. E. Sumpio, W. Du, G. Galagher, X.-j. Wang, L. M. Khachigian, T. Collins, M. A. Gimbrone Jr, and N. Resnick
Regulation of PDGF-B in Endothelial Cells Exposed to Cyclic Strain
Arterioscler Thromb Vasc Biol, March 1, 1998; 18(3): 349 - 355.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
A. Parenti, L. Morbidelli, X.-L. Cui, J. G. Douglas, J. D. Hood, H. J. Granger, F. Ledda, and M. Ziche
Nitric Oxide Is an Upstream Signal of Vascular Endothelial Growth Factor-induced Extracellular Signal-regulated Kinase1/2 Activation in Postcapillary Endothelium
J. Biol. Chem., February 13, 1998; 273(7): 4220 - 4226.
[Abstract] [Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
S. Jalali, Y.-S. Li, M. Sotoudeh, S. Yuan, S. Li, S. Chien, and J. Y-J. Shyy
Shear Stress Activates p60src-Ras-MAPK Signaling Pathways in Vascular Endothelial Cells
Arterioscler Thromb Vasc Biol, February 1, 1998; 18(2): 227 - 234.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
M. Papadaki, R. G. Tilton, S. G. Eskin, and L. V. McIntire
Nitric oxide production by cultured human aortic smooth muscle cells: stimulation by fluid flow
Am J Physiol Heart Circ Physiol, February 1, 1998; 274(2): H616 - H626.
[Abstract] [Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
E. M. Redmond, P. A. Cahill, and J. V. Sitzmann
Flow-Mediated Regulation of G-Protein Expression in Cocultured Vascular Smooth Muscle and Endothelial Cells
Arterioscler Thromb Vasc Biol, January 1, 1998; 18(1): 75 - 83.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
J. S. Mondy, V. Lindner, J. K. Miyashiro, B. C. Berk, R. H. Dean, and R. L. Geary
Platelet-Derived Growth Factor Ligand and Receptor Expression in Response to Altered Blood Flow In Vivo
Circ. Res., September 19, 1997; 81(3): 320 - 327.
[Abstract] [Full Text]

Home page
 Circ. Res.Home page
B. S. Wung, J. J. Cheng, H. J. Hsieh, Y. J. Shyy, and D. L. Wang
Cyclic Strain–Induced Monocyte Chemotactic Protein-1 Gene Expression in Endothelial Cells Involves Reactive Oxygen Species Activation of Activator Protein 1
Circ. Res., July 19, 1997; 81(1): 1 - 7.
[Abstract] [Full Text]

Home page
 Circ. Res.Home page
J. L. Unthank, S. W. Fath, H. M. Burkhart, S. C. Miller, and M. C. Dalsing
Wall Remodeling During Luminal Expansion of Mesenteric Arterial Collaterals in the Rat
Circ. Res., November 1, 1996; 79(5): 1015 - 1023.
[Abstract] [Full Text]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
G. Dai, O. Tsukurov, M. Chen, J. P. Gertler, and R. D. Kamm
Endothelial nitric oxide production during in vitro simulation of external limb compression
Am J Physiol Heart Circ Physiol, June 1, 2002; 282(6): H2066 - H2075.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online