AJP - Heart Watch the video to learn how APS reaches out to developing nations.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Heart Circ Physiol 269: H669-H675, 1995;
0363-6135/95 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Smolich, J. J.
Right arrow Articles by Woods, R. L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Smolich, J. J.
Right arrow Articles by Woods, R. L.

AJP - Heart and Circulatory Physiology, Vol 269, Issue 2 669-H675, Copyright © 1995 by American Physiological Society

ARTICLES

Regional systemic ANP differences in fetal lambs: role of coronary sinus outflow distribution

J. J. Smolich and R. L. Woods
Institute of Reproduction and Development, Monash University, Clayton, Victoria, Australia.

Although it is known that the atrial natriuretic peptide (ANP) level in right ventricular (RV) blood supplying the caudal part of the fetus is greater than in left ventricular blood perfusing the cephalic part of the fetus, the extent to which any preferential passage of coronary sinus blood into the right ventricle contributes to regional differences between ANP levels in fetal cephalic and caudal arteries is unknown. To address this question, experiments were performed in eight late-gestation fetal lambs, 3-7 days after catheters were inserted into the left atrium, major arteries and veins, and coronary sinus (via the left hemiazygous vein). The plasma ANP level in the abdominal aorta (171 +/- 33 pg/ml) was higher than in the carotid artery (103 +/- 15 pg/ml; P < 0.05), and both were lower than in the coronary sinus (736 +/- 89 pg/ml; P < 0.005). The coronary sinus outflow, measured with radioactive microspheres injected into the hemiazygous vein, was preferentially distributed to the right ventricle (94.7 +/- 1.3%) and thence to the abdominal aorta (89.5 +/- 1.6%). This streaming of the coronary sinus outflow contributed 13.3 +/- 0.9 and 1.4 +/- 0.4 pg/ml to ANP levels in the abdominal aorta and carotid artery, respectively, and thereby accounted for 11.9 +/- 0.9 pg/ml of the abdominal aorta-carotid artery ANP difference of 68 +/- 25 pg/ml.(ABSTRACT TRUNCATED AT 250 WORDS)


This article has been cited by other articles:


Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
J. J. Smolich
NO supports right ventricular flow dominance and whole body O2 utilization in midgestation fetal lambs
Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2001; 280(4): R1016 - R1022.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
J. J. Smolich and M. D. Esler
Total body catecholamine kinetics before and after birth in spontaneously hypoxemic fetal lambs
Am J Physiol Regulatory Integrative Comp Physiol, November 1, 1999; 277(5): R1313 - R1320.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
J. J. Smolich
NO modulates fetoplacental blood flow distribution and whole body oxygen extraction in fetal sheep
Am J Physiol Regulatory Integrative Comp Physiol, May 1, 1998; 274(5): R1331 - R1337.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
J. J. Smolich, H. S. Cox, P. J. Berger, A. M. Walker, G. Eisenhofer, and M. D. Esler
Left Ventricular Norepinephrine and Epinephrine Kinetics at Birth in Lambs
Circ. Res., September 19, 1997; 81(3): 438 - 447.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online