| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
AJP - Heart and Circulatory Physiology, Vol 269, Issue 3 863-H868, Copyright © 1995 by American Physiological Society
ARTICLES |
S. Kato, F. G. Spinale, R. Tanaka, W. Johnson, G. Cooper 4th and M. R. Zile
Gazes Cardiac Research Institute, Department of Medicine, Medical University of South Carolina, Charleston 29425, USA.
The fibrillar collagen network is postulated to be a primary determinant of left ventricular diastolic stiffness. This hypothesis was tested by examining the structural and physiological effects of a reduction in fibrillar collagen content and cross-linking in the intact left ventricle. Collagen cross-linking was inhibited by treating five normal adult pigs with beta-aminopropionitrile (BAPN; 10 g/day po) for 6 wk; five normal untreated pigs served as controls. Left ventricular volume, mass, and function were determined by simultaneous echocardiography and catheterization. Chamber stiffness, defined by pressure vs. volume data, and myocardial stiffness, defined by stress vs. dimension data, were determined from variably loaded beats during dextran infusion. Collagen distribution (% area) and integrity (% confluence) were determined by light microscopy. Collagen content was measured by hydroxyproline assay, and collagen cross-linking was measured by salt extraction. BAPN decreased collagen distribution (% area decreased from 12 +/- 1% in control to 7 +/- 1% in BAPN, P < 0.05), collagen integrity (% confluence decreased from 8 +/- 1% in control to 4 +/- 1% in BAPN, P < 0.05), collagen content (from 36 +/- 2 mg/g dry wt in control to 27 +/- 2 mg/g dry wt in BAPN, P < 0.05), and collagen cross-linking (extractable collagen increased from 21 +/- 2% in control to 28 +/- 2% in BAPN, P < 0.05). BAPN decreased chamber stiffness (0.13 +/- 0.02 in control to 0.06 +/- 0.01 in BAPN, P < 0.05) and myocardial stiffness (10.4 +/- 0.5 in control to 6.6 +/- 0.5 in BAPN, P < 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)
This article has been cited by other articles:
|
|
 |
|
  F. G. Spinale Myocardial Matrix Remodeling and the Matrix Metalloproteinases: Influence on Cardiac Form and Function Physiol Rev, October 1, 2007; 87(4): 1285 - 1342. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Poobalarahi, C. F. Baicu, and A. D. Bradshaw Cardiac myofibroblasts differentiated in 3D culture exhibit distinct changes in collagen I production, processing, and matrix deposition Am J Physiol Heart Circ Physiol, December 1, 2006; 291(6): H2924 - H2932. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Westerhof, C. Boer, R. R. Lamberts, and P. Sipkema Cross-talk between cardiac muscle and coronary vasculature. Physiol Rev, October 1, 2006; 86(4): 1263 - 1308. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. M. Alwardt, Q. Yu, H. L. Brooks, M. R. McReynolds, R. Vazquez, R. R. Watson, and D. F. Larson Comparative effects of dehydroepiandrosterone sulfate on ventricular diastolic function with young and aged female mice Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2006; 290(1): R251 - R256. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Q. Yu, R. R. Watson, J. J. Marchalonis, and D. F. Larson A role for T lymphocytes in mediating cardiac diastolic function Am J Physiol Heart Circ Physiol, August 1, 2005; 289(2): H643 - H651. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Klotz, R. F. Foronjy, M. L. Dickstein, A. Gu, I. M. Garrelds, A.H. Jan Danser, M. C. Oz, J. D'Armiento, and D. Burkhoff Mechanical Unloading During Left Ventricular Assist Device Support Increases Left Ventricular Collagen Cross-Linking and Myocardial Stiffness Circulation, July 19, 2005; 112(3): 364 - 374. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. D. Zimmerman, J. Criscione, and J. W. Covell Remodeling in myocardium adjacent to an infarction in the pig left ventricle Am J Physiol Heart Circ Physiol, December 1, 2004; 287(6): H2697 - H2704. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Gibbs, D. G. A. Veliotes, C. Anamourlis, D. Badenhorst, O. Osadchii, G. R. Norton, and A. J. Woodiwiss Chronic {beta}-adrenoreceptor activation increases cardiac cavity size through chamber remodeling and not via modifications in myocardial material properties Am J Physiol Heart Circ Physiol, December 1, 2004; 287(6): H2762 - H2767. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. L. Herrmann, A. D. McCulloch, and J. H. Omens Glycated collagen cross-linking alters cardiac mechanics in volume-overload hypertrophy Am J Physiol Heart Circ Physiol, April 1, 2003; 284(4): H1277 - H1284. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. F. Baicu, J. D. Stroud, V. A. Livesay, E. Hapke, J. Holder, F. G. Spinale, and M. R. Zile Changes in extracellular collagen matrix alter myocardial systolic performance Am J Physiol Heart Circ Physiol, January 1, 2003; 284(1): H122 - H132. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. D. Stroud, C. F. Baicu, M. A. Barnes, F. G. Spinale, and M. R. Zile Viscoelastic properties of pressure overload hypertrophied myocardium: effect of serine protease treatment Am J Physiol Heart Circ Physiol, June 1, 2002; 282(6): H2324 - H2335. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. R. Zile and D. L. Brutsaert New Concepts in Diastolic Dysfunction and Diastolic Heart Failure: Part II: Causal Mechanisms and Treatment Circulation, March 26, 2002; 105(12): 1503 - 1508. [Full Text] [PDF]
|
|
|
|
 |
|
 S. M. Weis, J. L. Emery, K. D. Becker, D. J. McBride Jr, J. H. Omens, and A. D. McCulloch Myocardial Mechanics and Collagen Structure in the Osteogenesis Imperfecta Murine (oim) Circ. Res., October 13, 2000; 87(8): 663 - 669. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. H. Lorell and B. A. Carabello Left Ventricular Hypertrophy : Pathogenesis, Detection, and Prognosis Circulation, July 25, 2000; 102(4): 470 - 479. [Full Text] [PDF]
|
|
|
|
|
|
F. G. Spinale, M. L. Coker, S. R. Krombach, R. Mukherjee, H. Hallak, W. V. Houck, M. J. Clair, S. B. Kribbs, L. L. Johnson, J. T. Peterson, et al. Matrix Metalloproteinase Inhibition During the Development of Congestive Heart Failure : Effects on Left Ventricular Dimensions and Function Circ. Res., August 20, 1999; 85(4): 364 - 376. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. R. Zile, K. Richardson, M. K. Cowles, J. M. Buckley, M. Koide, B. A. Cowles, V. Gharpuray, and G. Cooper IV Constitutive Properties of Adult Mammalian Cardiac Muscle Cells Circulation, August 11, 1998; 98(6): 567 - 579. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. R. Zile, M. K. Cowles, J. M. Buckley, K. Richardson, B. A. Cowles, C. F. Baicu, G. Cooper IV, and V. Gharpuray Gel stretch method: a new method to measure constitutive properties of cardiac muscle cells Am J Physiol Heart Circ Physiol, June 1, 1998; 274(6): H2188 - H2202. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. R. Norton, J. Tsotetsi, B. Trifunovic, C. Hartford, G. P. Candy, and A. J. Woodiwiss Myocardial Stiffness Is Attributed to Alterations in Cross-Linked Collagen Rather Than Total Collagen or Phenotypes in Spontaneously Hypertensive Rats Circulation, September 16, 1997; 96(6): 1991 - 1998. [Abstract] [Full Text]
|
|
|
|
 |
|
 M. Asif, J. Egan, S. Vasan, G. N. Jyothirmayi, M. R. Masurekar, S. Lopez, C. Williams, R. L. Torres, D. Wagle, P. Ulrich, et al. An advanced glycation endproduct cross-link breaker can reverse age-related increases in myocardial stiffness PNAS, March 14, 2000; 97(6): 2809 - 2813. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
