| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
AJP - Heart and Circulatory Physiology, Vol 269, Issue 6 2022-H2030, Copyright © 1995 by American Physiological Society
ARTICLES |
J. Xia and B. R. Duling
Department of Molecular Physiology and Biological Physics, School of Medicine, University of Virginia, Charlottesville 22908, USA.
Conducted vasomotor responses are viewed as one mechanism that functionally integrates the microvasculature. It is hypothesized that the conducted vasomotor response is the result of an electrical current and its passive electrotonic spread along the length of a microvessel. We tested this hypothesis in isolated, unpressurized arterioles from the hamster cheek pouch using conventional intracellular membrane potential recording techniques. The mean resting membrane potential (RMP) was -67 mV. KCl and phenylephrine (PE) pulse-stimulation applied through micropipettes could both induce transient depolarizations and vasoconstrictions at the site of stimulation (local) and at conducted (560 microns) sites. It was noted, however, that the conducted vasomotor response could not be induced until the conducted electrical response exceeded a threshold of -45 mV for a minimum amount of time. The relationship between the amplitude of constriction and the amplitude-time area of depolarization above -45 mV was the same for local and conducted KCl and for conducted PE but was significantly different from that for local PE. Nifedipine greatly reduced the local and conducted mechanical but not electrical responses. Our results indicate that the conducted vasomotor responses are the result of the generation and subsequent conduction of electrical signals along the vessel but that the corresponding mechanical response occurs only when the electrical response exceeds a threshold level.
This article has been cited by other articles:
|
|
 |
|
  X. F. Figueroa and B. R. Duling Dissection of two Cx37-independent conducted vasodilator mechanisms by deletion of Cx40: electrotonic versus regenerative conduction Am J Physiol Heart Circ Physiol, November 1, 2008; 295(5): H2001 - H2007. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. C. Arciero, B. E. Carlson, and T. W. Secomb Theoretical model of metabolic blood flow regulation: roles of ATP release by red blood cells and conducted responses Am J Physiol Heart Circ Physiol, October 1, 2008; 295(4): H1562 - H1571. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. E. Carlson, J. C. Arciero, and T. W. Secomb Theoretical model of blood flow autoregulation: roles of myogenic, shear-dependent, and metabolic responses Am J Physiol Heart Circ Physiol, October 1, 2008; 295(4): H1572 - H1579. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. M. Sorensen, M. Salomonsson, T. H. Braunstein, M. S. Nielsen, and N.-H. Holstein-Rathlou Connexin mimetic peptides fail to inhibit vascular conducted calcium responses in renal arterioles Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2008; 295(3): R840 - R847. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. F. Figueroa, C.-C. Chen, K. P. Campbell, D. N. Damon, K. H. Day, S. Ramos, and B. R. Duling Are voltage-dependent ion channels involved in the endothelial cell control of vasomotor tone? Am J Physiol Heart Circ Physiol, September 1, 2007; 293(3): H1371 - H1383. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. L. Armstrong, A. K. Dua, and C. L. Murrant Potassium initiates vasodilatation induced by a single skeletal muscle contraction in hamster cremaster muscle J. Physiol., June 1, 2007; 581(2): 841 - 852. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. C. Jantzi, S. E. Brett, W. F. Jackson, R. Corteling, E. J. Vigmond, and D. G. Welsh Inward rectifying potassium channels facilitate cell-to-cell communication in hamster retractor muscle feed arteries Am J Physiol Heart Circ Physiol, September 1, 2006; 291(3): H1319 - H1328. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. T. Kurjiaka, S. B. Bender, D. D. Nye, W. B. Wiehler, and D. G. Welsh Hypertension attenuates cell-to-cell communication in hamster retractor muscle feed arteries Am J Physiol Heart Circ Physiol, February 1, 2005; 288(2): H861 - H870. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Earley, T. C. Resta, and B. R. Walker Disruption of smooth muscle gap junctions attenuates myogenic vasoconstriction of mesenteric resistance arteries Am J Physiol Heart Circ Physiol, December 1, 2004; 287(6): H2677 - H2686. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. C. Looft-Wilson, G. W. Payne, and S. S. Segal Connexin expression and conducted vasodilation along arteriolar endothelium in mouse skeletal muscle J Appl Physiol, September 1, 2004; 97(3): 1152 - 1158. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. A. Dora, J. Xia, and B. R. Duling Endothelial cell signaling during conducted vasomotor responses Am J Physiol Heart Circ Physiol, June 5, 2003; 285(1): H119 - H126. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Yashiro and B. R. Duling Participation of intracellular Ca2+ stores in arteriolar conducted responses Am J Physiol Heart Circ Physiol, June 5, 2003; 285(1): H65 - H73. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Hoepfl, B. Rodenwaldt, U. Pohl, and C. de Wit EDHF, but not NO or prostaglandins, is critical to evoke a conducted dilation upon ACh in hamster arterioles Am J Physiol Heart Circ Physiol, September 1, 2002; 283(3): H996 - H1004. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Salomonsson, F. Gustafsson, D. Andreasen, B. L. Jensen, and N.-H. Holstein-Rathlou Local electric stimulation causes conducted calcium response in rat interlobular arteries Am J Physiol Renal Physiol, September 1, 2002; 283(3): F473 - F480. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. G. Emerson, T. O. Neild, and S. S. Segal Conduction of hyperpolarization along hamster feed arteries: augmentation by acetylcholine Am J Physiol Heart Circ Physiol, July 1, 2002; 283(1): H102 - H109. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Tyml, X. Wang, D. Lidington, and Y. Ouellette Lipopolysaccharide reduces intercellular coupling in vitro and arteriolar conducted response in vivo Am J Physiol Heart Circ Physiol, September 1, 2001; 281(3): H1397 - H1406. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Hill, H. Zou, S. J. Potocnik, G. A. Meininger, and M. J. Davis Signal Transduction in Smooth Muscle: Invited Review: Arteriolar smooth muscle mechanotransduction: Ca2+ signaling pathways underlying myogenic reactivity J Appl Physiol, August 1, 2001; 91(2): 973 - 983. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Gustafsson, D. Andreasen, M. Salomonsson, B. L. Jensen, and N.-H. Holstein-Rathlou Conducted vasoconstriction in rat mesenteric arterioles: role for dihydropyridine-insensitive Ca2+ channels Am J Physiol Heart Circ Physiol, February 1, 2001; 280(2): H582 - H590. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Yashiro and B. R. Duling Integrated Ca2+ Signaling Between Smooth Muscle and Endothelium of Resistance Vessels Circ. Res., November 24, 2000; 87(11): 1048 - 1054. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. L. Murrant and I. H. Sarelius Local and remote arteriolar dilations initiated by skeletal muscle contraction Am J Physiol Heart Circ Physiol, November 1, 2000; 279(5): H2285 - H2294. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. G. Emerson and S. S. Segal Electrical Coupling Between Endothelial Cells and Smooth Muscle Cells in Hamster Feed Arteries : Role in Vasomotor Control Circ. Res., September 15, 2000; 87(6): 474 - 479. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. A. Dora, D. N. Damon, and B. R. Duling Microvascular dilation in response to occlusion: a coordinating role for conducted vasomotor responses Am J Physiol Heart Circ Physiol, July 1, 2000; 279(1): H279 - H284. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. D. Cohen, B. R. Berg, and I. H. Sarelius Remote arteriolar dilations in response to muscle contraction under capillaries Am J Physiol Heart Circ Physiol, June 1, 2000; 278(6): H1916 - H1923. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. D. Frame Increased flow precedes remote arteriolar dilations for some microapplied agonists Am J Physiol Heart Circ Physiol, April 1, 2000; 278(4): H1186 - H1195. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. de Wit, F. Roos, S.-S. Bolz, S. Kirchhoff, O. Kruger, K. Willecke, and U. Pohl Impaired Conduction of Vasodilation Along Arterioles in Connexin40-Deficient Mice Circ. Res., March 31, 2000; 86(6): 649 - 655. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. S. Bartlett and S. S. Segal Resolution of smooth muscle and endothelial pathways for conduction along hamster cheek pouch arterioles Am J Physiol Heart Circ Physiol, February 1, 2000; 278(2): H604 - H612. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. E. HUNGERFORD, W. C. SESSA, and S. S. SEGAL Vasomotor control in arterioles of the mouse cremaster muscle FASEB J, January 1, 2000; 14(1): 197 - 207. [Abstract] [Full Text]
|
|
|
|
 |
|
 M. J. Davis and M. A. Hill Signaling Mechanisms Underlying the Vascular Myogenic Response Physiol Rev, April 1, 1999; 79(2): 387 - 423. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. D. S. Frame Conducted signals within arteriolar networks initiated by bioactive amino acids Am J Physiol Heart Circ Physiol, March 1, 1999; 276(3): H1012 - H1021. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. R. Pries, T. W. Secomb, and P. Gaehtgens Structural adaptation and stability of microvascular networks: theory and simulations Am J Physiol Heart Circ Physiol, August 1, 1998; 275(2): H349 - H360. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. G. Welsh, W. F. Jackson, and S. S. Segal Oxygen induces electromechanical coupling in arteriolar smooth muscle cells: a role for L-type Ca2+ channels Am J Physiol Heart Circ Physiol, June 1, 1998; 274(6): H2018 - H2024. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. D. McGahren, J. M. Beach, and B. R. Duling Capillaries demonstrate changes in membrane potential in response to pharmacological stimuli Am J Physiol Heart Circ Physiol, January 1, 1998; 274(1): H60 - H65. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. G. Welsh and S. S. Segal Endothelial and smooth muscle cell conduction in arterioles controlling blood flow Am J Physiol Heart Circ Physiol, January 1, 1998; 274(1): H178 - H186. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Xia and B. R. Duling Patterns of excitation-contraction coupling in arterioles: dependence on time and concentration Am J Physiol Heart Circ Physiol, January 1, 1998; 274(1): H323 - H330. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. L. Jasperse and M. H. Laughlin Flow-induced dilation of rat soleus feed arteries Am J Physiol Heart Circ Physiol, November 1, 1997; 273(5): H2423 - H2427. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. A. Dora, M. P. Doyle, and B. R. Duling Elevation of intracellular calcium in smooth muscle causes endothelial cell generation of NO in arterioles PNAS, June 10, 1997; 94(12): 6529 - 6534. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. J. Christ, D. C. Spray, M. El-Sabban, L. K. Moore, and P. R. Brink Gap Junctions in Vascular Tissues: Evaluating the Role of Intercellular Communication in the Modulation of Vasomotor Tone Circ. Res., October 1, 1996; 79(4): 631 - 646. [Abstract] [Full Text]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
