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Am J Physiol Heart Circ Physiol 269: H2141-H2146, 1995;
0363-6135/95 $5.00
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AJP - Heart and Circulatory Physiology, Vol 269, Issue 6 2141-H2146, Copyright © 1995 by American Physiological Society

ARTICLES

Explorations into development of a neurally regulated cardiac pacemaker

Y. Ikeda, M. Sugimachi, T. Yamasaki, O. Kawaguchi, T. Shishido, T. Kawada, J. Alexander Jr and K. Sunagawa
Department of Cardiovascular Dynamics, National Cardiovascular Center Research Institute, Osaka, Japan.

Although the artificial cardiac pacemaker has contributed to the management of patients with serious arrhythmias, its rate-responsive function is not sufficient to provide physiological regulation of heart rate (HR). To achieve truly physiological rate response in any given patient, we propose a framework to develop a pacemaker directly regulated by sympathetic nerve activity (SNA). In eight anesthetized rabbits, we quantified the dynamic transduction characteristics from SNA to HR as a transfer function. We then characterized the decoding rule as an impulse response, that is the transfer characteristics in the time domain. The transfer function was approximated by a first-order, low-pass filter with lag time (corner frequency: 0.024 +/- 0.013 Hz, lag time: 0.98 +/- 0.09 s). Predicted HR correlated well with measured HR (r = 0.80-0.98). The standard error of the prediction relative to mean HR was only 1.2 +/- 0.7%, indicating that the prediction was reasonably accurate. Direct decoding of SNA to predict instantaneous HR is possible through this analysis. This framework should enable development of a neurally regulated artificial pacemaker.


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