AJP - Heart and Circulatory Physiology, Vol 270, Issue 2 685-H691, Copyright © 1996 by American Physiological Society
Early changes in protein synthesis in epicardial coronary artery of pressure-overloaded heart
M. Gerova, O. Pechanova, V. Stoev, M. Kittova, I. Bernatova and E. Barta
Institute of Normal and Pathological Physiology, Slovak Academy of Sciences, Bratislava, Slovak Republic.
In anesthetized dogs, a 4-h, approximately 30% increase in blood pressure
induced by constriction of the abdominal aorta brought about an increase in
the total RNA content in the left anterior descending coronary artery
(LADCA) and the left ventricular (LV) myocardium (9.05 +/- 1.72 and 11.06
+/- 4.68%, respectively) but not in the left circumflex coronary artery
(LCCA). Under the same experimental conditions, [14C]leucine incorporation
increased in LADCA and LV myocardium (45.34 +/- 13.54 and 58.07 +/- 11.91%,
respectively), but not in LCCA. The data indicate an early shift in protein
synthesis in LADCA and simultaneously in the myocardium during a short-term
pressor event. The difference in the shift of protein synthesis in the two
main branches of the left coronary artery was related to the quantitatively
different deformation of the LADCA and LCCA due to different deformation of
the underlying myocardium and/or of the annulus fibrosus atrioventricularis
during changes in the left or right ventricle volume [M. Gerova, E. Barta,
M. Stolarik, and J. Gero, Am. J. Physiol. 262 (Heart Circ. Physiol. 31):
H1049-H1053, 1992]. The results support the hypothesis that the deformation
and/or rate of deformation of cells in the coronary wall may trigger an
increase in protein synthesis. Changes in protein synthesis in the
myocardium and LADCA were found to be reversible 2 h after releasing the
aortic constriction.
