| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
AJP - Heart and Circulatory Physiology, Vol 270, Issue 3 1044-H1053, Copyright © 1996 by American Physiological Society
ARTICLES |
K. M. Mohazzab-H, P. M. Kaminski, R. P. Fayngersh and M. S. Wolin
Department of Physiology, New York Medical College, Valhalla 10595, USA.
Our previous studies in isolated endothelium-removed calf pulmonary arteries suggest that PO2-elicited responses are primarily mediated through modulation of guanosine 3',5'-cyclic monophosphate via changes in the generation of H2O2 originating from superoxide anion (O2-.) produced by NADH oxidase activity. In the present study we examined the importance of this mechanism in PO2-elicited responses of endothelium-removed calf coronary arteries. NADH oxidase activity was found to be the major source of O2-. in the homogenate of endothelium-removed calf coronary arteries detected by lucigenin-elicited chemiluminescence. Precontracted endothelium-removed calf coronary arteries show a relaxation to hypoxia, and reoxygenation causes a transient additional relaxation before the recovery of normoxic levels of force. Under these conditions the detection of O2-. was decreased by hypoxia and a transient overproduction was observed during reoxygenation. The relaxation to reoxygenation, but not to hypoxia, was significantly inhibited by a scavenger of O2-. that prevents the formation of H2O2 (nitro blue tetrazolium), an inhibitor of NAD(P)H oxidases and other O2(-.)-generating flavoproteins (diphenyliodonium), and inhibition of the stimulation of soluble guanylate cyclase (LY-83583). A scavenger of O2-. that promotes H2O2 formation (Tiron) did not inhibit the PO2-elicited responses examined. Hypoxia and diphenyliodonium (but not Tiron) decreased the metabolism of endogenous H2O2 by catalase (as measured by the H2O2-dependent co-oxidation of methanol to formaldehyde by catalase), and reoxygenation caused a stimulation of H2O2 metabolism by catalase. The presence of endothelium resulted in minor modifications of the PO2 responses, which were partially mediated via prostaglandins and nitric oxide on the basis of the effects of indomethacin and nitro-L-arginine, respectively. These results suggest that in calf coronary arteries the stimulation of guanylate cyclase via H2O2 originating from NADH-derived O2-(.) production contributes to the transient relaxation to posthypoxic reoxygenation, but not the response to hypoxia.
This article has been cited by other articles:
|
|
 |
|
  Q. Gao, X. Zhao, M. Ahmad, and M. S. Wolin Mitochondrial-derived hydrogen peroxide inhibits relaxation of bovine coronary arterial smooth muscle to hypoxia through stimulation of ERK MAP kinase Am J Physiol Heart Circ Physiol, December 1, 2009; 297(6): H2262 - H2269. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. S. Wolin Reactive oxygen species and the control of vascular function Am J Physiol Heart Circ Physiol, March 1, 2009; 296(3): H539 - H549. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Q. Gao and M. S. Wolin Effects of hypoxia on relationships between cytosolic and mitochondrial NAD(P)H redox and superoxide generation in coronary arterial smooth muscle Am J Physiol Heart Circ Physiol, September 1, 2008; 295(3): H978 - H989. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Chen, A. Pearlman, Z. Luo, and C. S. Wilcox Hydrogen peroxide mediates a transient vasorelaxation with tempol during oxidative stress Am J Physiol Heart Circ Physiol, October 1, 2007; 293(4): H2085 - H2092. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Wei, Z. Wang, E. Babilonia, H. Sterling, P. Sun, and W. Wang Effect of hydrogen peroxide on ROMK channels in the cortical collecting duct Am J Physiol Renal Physiol, April 1, 2007; 292(4): F1151 - F1156. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. T. Larsen and D. D. Gutterman Hypoxia, coronary dilation, and the pentose phosphate pathway Am J Physiol Heart Circ Physiol, June 1, 2006; 290(6): H2169 - H2171. [Full Text] [PDF]
|
|
|
|
|
|
S. A. Gupte and M. S. Wolin Hypoxia promotes relaxation of bovine coronary arteries through lowering cytosolic NADPH Am J Physiol Heart Circ Physiol, June 1, 2006; 290(6): H2228 - H2238. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X.-Y. Yi, V. X. Li, F. Zhang, F. Yi, D. R. Matson, M. T. Jiang, and P.-L. Li Characteristics and actions of NAD(P)H oxidase on the sarcoplasmic reticulum of coronary artery smooth muscle Am J Physiol Heart Circ Physiol, March 1, 2006; 290(3): H1136 - H1144. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Chen, P. S. Gill, and W. J. Welch Oxygen availability limits renal NADPH-dependent superoxide production Am J Physiol Renal Physiol, October 1, 2005; 289(4): F749 - F753. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. S. Wolin, M. Ahmad, and S. A. Gupte Oxidant and redox signaling in vascular oxygen sensing mechanisms: basic concepts, current controversies, and potential importance of cytosolic NADPH Am J Physiol Lung Cell Mol Physiol, August 1, 2005; 289(2): L159 - L173. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Turkseven, A. Kruger, C. J. Mingone, P. Kaminski, M. Inaba, L. F. Rodella, S. Ikehara, M. S. Wolin, and N. G. Abraham Antioxidant mechanism of heme oxygenase-1 involves an increase in superoxide dismutase and catalase in experimental diabetes Am J Physiol Heart Circ Physiol, August 1, 2005; 289(2): H701 - H707. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. A. Oeckler, E. Arcuino, M. Ahmad, S. C. Olson, and M. S. Wolin Cytosolic NADH redox and thiol oxidation regulate pulmonary arterial force through ERK MAP kinase Am J Physiol Lung Cell Mol Physiol, June 1, 2005; 288(6): L1017 - L1025. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. A. Gupte, P. M. Kaminski, B. Floyd, R. Agarwal, N. Ali, M. Ahmad, J. Edwards, and M. S. Wolin Cytosolic NADPH may regulate differences in basal Nox oxidase-derived superoxide generation in bovine coronary and pulmonary arteries Am J Physiol Heart Circ Physiol, January 1, 2005; 288(1): H13 - H21. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Thengchaisri and L. Kuo Hydrogen peroxide induces endothelium-dependent and -independent coronary arteriolar dilation: role of cyclooxygenase and potassium channels Am J Physiol Heart Circ Physiol, December 1, 2003; 285(6): H2255 - H2263. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. A. Gupte, M. Arshad, S. Viola, P. M. Kaminski, Z. Ungvari, G. Rabbani, A. Koller, and M. S. Wolin Pentose phosphate pathway coordinates multiple redox-controlled relaxing mechanisms in bovine coronary arteries Am J Physiol Heart Circ Physiol, December 1, 2003; 285(6): H2316 - H2326. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Zimpelmann, N. Li, and K. D. Burns Nitric oxide inhibits superoxide-stimulated urea permeability in the rat inner medullary collecting duct Am J Physiol Renal Physiol, December 1, 2003; 285(6): F1160 - F1167. [Abstract] [Full Text]
|
|
|
|
 |
|
 Z. Ungvari, A. Csiszar, J. G. Edwards, P. M. Kaminski, M. S. Wolin, G. Kaley, and A. Koller Increased Superoxide Production in Coronary Arteries in Hyperhomocysteinemia: Role of Tumor Necrosis Factor-{alpha}, NAD(P)H Oxidase, and Inducible Nitric Oxide Synthase Arterioscler Thromb Vasc Biol, March 1, 2003; 23(3): 418 - 424. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Meng, L. J. Roberts II, G. W. Cason, T. S. Curry, and R. D. Manning Jr. Superoxide dismutase and oxidative stress in Dahl salt-sensitive and -resistant rats Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2002; 283(3): R732 - R738. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Balazy, T. Iesaki, J. L. Park, H. Jiang, P. M. Kaminski, and M. S. Wolin Vicinal Nitrohydroxyeicosatrienoic Acids: Vasodilator Lipids Formed by Reaction of Nitrogen Dioxide with Arachidonic Acid J. Pharmacol. Exp. Ther., November 1, 2001; 299(2): 611 - 619. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. P. Didion, C. A. Hathaway, and F. M. Faraci Superoxide levels and function of cerebral blood vessels after inhibition of CuZn-SOD Am J Physiol Heart Circ Physiol, October 1, 2001; 281(4): H1697 - H1703. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Zanetti, J.'I. Sato, Z. S. Katusic, and T. O'Brien Gene transfer of superoxide dismutase isoforms reverses endothelial dysfunction in diabetic rabbit aorta Am J Physiol Heart Circ Physiol, June 1, 2001; 280(6): H2516 - H2523. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A.-P. Zou, N. Li, and A. W. Cowley Jr. Production and Actions of Superoxide in the Renal Medulla Hypertension, February 1, 2001; 37(2): 547 - 553. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Iesaki and M. S. Wolin Thiol Oxidation Activates a Novel Redox-Regulated Coronary Vasodilator Mechanism Involving Inhibition of Ca2+ Influx Arterioscler Thromb Vasc Biol, November 1, 2000; 20(11): 2359 - 2365. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. M. Channon, H. Qian, and S. E. George Nitric Oxide Synthase in Atherosclerosis and Vascular Injury : Insights From Experimental Gene Therapy Arterioscler Thromb Vasc Biol, August 1, 2000; 20(8): 1873 - 1881. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. K. Griendling, D. Sorescu, and M. Ushio-Fukai NAD(P)H Oxidase : Role in Cardiovascular Biology and Disease Circ. Res., March 17, 2000; 86(5): 494 - 501. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Moldovan, N. I. Moldovan, R. H. Sohn, S. A. Parikh, and P. J. Goldschmidt-Clermont Redox Changes of Cultured Endothelial Cells and Actin Dynamics Circ. Res., March 17, 2000; 86(5): 549 - 557. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Iesaki, S. A. Gupte, and M. S. Wolin A Flavoprotein Mechanism Appears to Prevent an Oxygen-Dependent Inhibition of cGMP-Associated Nitric Oxide-Elicited Relaxation of Bovine Coronary Arteries Circ. Res., November 26, 1999; 85(11): 1027 - 1031. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Iesaki, S. A. Gupte, P. M. Kaminski, and M. S. Wolin Inhibition of guanylate cyclase stimulation by NO and bovine arterial relaxation to peroxynitrite and H2O2 Am J Physiol Heart Circ Physiol, September 1, 1999; 277(3): H978 - H985. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Patterson, J. Ruef, N. R. Madamanchi, P. Barry-Lane, Z. Hu, C. Horaist, C. A. Ballinger, A. R. Brasier, C. Bode, and M. S. Runge Stimulation of a Vascular Smooth Muscle Cell NAD(P)H Oxidase by Thrombin. EVIDENCE THAT p47phox MAY PARTICIPATE IN FORMING THIS OXIDASE IN VITRO AND IN VIVO J. Biol. Chem., July 9, 1999; 274(28): 19814 - 19822. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. S. Brar, T. P. Kennedy, A. R. Whorton, T. M. Murphy, P. Chitano, and J. R. Hoidal Requirement for Reactive Oxygen Species in Serum-induced and Platelet-derived Growth Factor-induced Growth of Airway Smooth Muscle J. Biol. Chem., July 9, 1999; 274(28): 20017 - 20026. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. A. Sanders, T. Huecksteadt, P. Xu, A. B. Sturrock, and J. R. Hoidal Regulation of Oxidant Production in Acute Lung Injury Chest, July 1, 1999; 116 (2009): 56S - 61S. [Full Text]
|
|
|
|
|
|
K. M. Mohazzab-H., R. Agarwal, and M. S. Wolin Influence of glutathione peroxidase on coronary artery responses to alterations in PO2 and H2O2 Am J Physiol Heart Circ Physiol, January 1, 1999; 276(1): H235 - H241. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Weissmann, F. Grimminger, R. Voswinckel, J. Conzen, and W. Seeger Nitro blue tetrazolium inhibits but does not mimic hypoxic vasoconstriction in isolated rabbit lungs Am J Physiol Lung Cell Mol Physiol, May 1, 1998; 274(5): L721 - L727. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. M. Mohazzab-H., P. M. Kaminski, and M. S. Wolin Lactate and PO2 Modulate Superoxide Anion Production in Bovine Cardiac Myocytes : Potential Role of NADH Oxidase Circulation, July 15, 1997; 96(2): 614 - 620. [Abstract] [Full Text]
|
|
|
|
|
|
D. Fulton, J. C. McGiff, M. S. Wolin, P. Kaminski, and J. Quilley Evidence against a Cytochrome P450-Derived Reactive Oxygen Species as the Mediator of the Nitric Oxide-Independent Vasodilator Effect of Bradykinin in the Perfused Heart of the Rat J. Pharmacol. Exp. Ther., February 1, 1997; 280(2): 702 - 709. [Abstract] [Full Text]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
