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AJP - Heart and Circulatory Physiology, Vol 270, Issue 4 1217-H1224, Copyright © 1996 by American Physiological Society
ARTICLES |
N. B. Ingels Jr, G. T. Daughters, S. D. Nikolic, A. DeAnda, M. R. Moon, A. F. Bolger, M. Komeda, G. C. Derby, E. L. Yellin and D. C. Miller
Department of Cardiovascular Physiology and Biophysics, Palo Alto Medical Foundation 94301, USA. (With the Technical Assistance of Cynthia E. Handen, Mary K. Zasio, and Erin M. Schultz.)
We investigated left ventricular (LV) diastolic volume changes (suction inflows) with left atrial pressure (LAP) clamped to ambient pressure in six open-chest, anesthetized dogs. The left atrium was cannulated and connected to a servo pump, and LAP was clamped to a set point near 0 mmHg for four beats by withdrawing blood. LAP averaged 5.88 +/- 1.44 mmHg before the clamp and fell to 0.74 +/- 0.61 mmHg (P < 0.0001) after the clamp. During the first clamped beat a transmitral pressure gradient of 1.0 +/- 0.6 mmHg was observed, resulting in LV filling of 2.6 +/- 1.8 ml. Subsequent beats developed suction-driven (mean negative LV pressure: -1.5 +/- 1.3 mmHg; P < 0.005 vs. zero) LV filling of 4.5 +/- 2.8 ml/beat with a peak transmitral pressure gradient of 1.7 +/- 0.6 mmHg. These data are consistent with the hypothesis that LV suction can be an important filling mechanism under condition in which LV end-systolic volume is reduced, e.g., reduced filling pressures, high heart rates, exercise, or increased inotropic drive.
This article has been cited by other articles:
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  W. Zhang, C. S. Chung, L. Shmuylovich, and S. J. Kovacs Is left ventricular volume during diastasis the real equilibrium volume, and what is its relationship to diastolic suction? J Appl Physiol, September 1, 2008; 105(3): 1012 - 1014. [Full Text] [PDF]
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T. A. Dorfman, B. D. Rosen, M. A. Perhonen, T. Tillery, R. McColl, R. M. Peshock, and B. D. Levine Diastolic suction is impaired by bed rest: MRI tagging studies of diastolic untwisting J Appl Physiol, April 1, 2008; 104(4): 1037 - 1044. [Abstract] [Full Text] [PDF]
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 C. Carlhall, K. Kindberg, L. Wigstrom, G. T. Daughters, D. C. Miller, M. Karlsson, and N. B. Ingels Jr Contribution of mitral annular dynamics to LV diastolic filling with alteration in preload and inotropic state Am J Physiol Heart Circ Physiol, September 1, 2007; 293(3): H1473 - H1479. [Abstract] [Full Text] [PDF]
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M. M. Riordan and S. J. Kovacs Stiffness- and relaxation-based quantitation of radial left ventricular oscillations: elucidation of regional diastolic function mechanisms J Appl Physiol, May 1, 2007; 102(5): 1862 - 1870. [Abstract] [Full Text] [PDF]
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S. L. Gaynor, H. S. Maniar, S. M. Prasad, P. Steendijk, and M. R. Moon Reservoir and conduit function of right atrium: impact on right ventricular filling and cardiac output Am J Physiol Heart Circ Physiol, May 1, 2005; 288(5): H2140 - H2145. [Abstract] [Full Text] [PDF]
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Z. Wang, F. Jalali, Y.-H. Sun, J.-J. Wang, K. H. Parker, and J. V. Tyberg Assessment of left ventricular diastolic suction in dogs using wave-intensity analysis Am J Physiol Heart Circ Physiol, April 1, 2005; 288(4): H1641 - H1651. [Abstract] [Full Text] [PDF]
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G. S. Nelson, E. Y. Sayed-Ahmed, C. A. G. Kroeker, Y.-H. Sun, H. E. D. J. T. Keurs, N. G. Shrive, and J. V. Tyberg Compression of interventricular septum during right ventricular pressure loading Am J Physiol Heart Circ Physiol, June 1, 2001; 280(6): H2639 - H2648. [Abstract] [Full Text] [PDF]
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