| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
AJP - Heart and Circulatory Physiology, Vol 270, Issue 6 2014-H2020, Copyright © 1996 by American Physiological Society
ARTICLES |
A. J. Houben, N. C. Schaper, C. H. de Haan, F. C. Huvers, D. W. Slaaf, P. W. de Leeuw and C. Nieuwenhuijzen Kruseman
Department of Internal Medicine, University Hospital Maastricht, The Netherlands.
Hyperglycemia induces regional hemodynamic changes, as suggested by animal studies. These hemodynamic changes may play an initiating role in the pathogenesis of diabetic microangiopathy. The aim of the present study was to evaluate the effects of acute local hyperglycemia for 24 h on basal human forearm muscle and skin blood flow and endothelium-dependent and -independent vasoreactivity. Local hyperglycemia (approximately 15 mM) was induced by infusion of 5% glucose into the brachial artery of the nondominant arm. In control experiments, the same individual amount of glucose was infused intravenously in the dominant arm to correct for possible systemic effects of the infused glucose. Vasoreactivity of the forearm vasculature was evaluated by local infusion of acetylcholine (ACh), sodium nitroprusside (SNP), NG-monomethyl-L-arginine (L-NMMA), and norepinephrine (NE) into the brachial artery. Regional hemodynamic measurements were performed at baseline and after 6, 12, and 24 h of local hyperglycemia. Median (with interquartile range) basal forearm (muscle) blood flow (FBF) was not influenced by the 24-h local hyperglycemia [infused-to-contralateral arm FBF ratio for glucose 1.32 (1.16-1.64) vs. control 1.54 (1.34-1.69)]. Skin microcirculatory blood flow (laser Doppler flowmetry, LDF) was not influenced by the 24-h local hyperglycemia [LDF ratio for glucose 1.00 (0.62-1.56) vs control 0.80 (0.58-1.14)]. In addition, the vasoreactivity of both muscle and skin (not shown) vasculature to ACh [percent change in FBF ratio for glucose 167% (81-263) vs. control 148% (94-211)], SNP [for glucose 486% (178-586) vs. control 293% (196-454)], L-NMMA [for glucose -36% (-56 to -22) vs. control -41% (-51 to -24)], and NE [for glucose -48% (-72 to -41) vs. control -66% (-79 to -33)] was also not affected by the local hyperglycemia. Thus, in contrast to animal studies, our results suggest that a moderate-to-severe hyperglycemia does not affect the regulation of basal blood flow or endothelium-dependent or -independent vasoreactivity in humans.
This article has been cited by other articles:
|
|
 |
|
  P. H. McNulty, M. A. Tulli, B. J. Robertson, V. Lendel, L. A. Harach, S. Scott, and J. P. Boehmer Effect of simulated postprandial hyperglycemia on coronary blood flow in cardiac transplant recipients Am J Physiol Heart Circ Physiol, July 1, 2007; 293(1): H103 - H108. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. E. J. Lott, C. Hogeman, M. Herr, R. Gabbay, and L. I. Sinoway Effects of an oral glucose tolerance test on the myogenic response in healthy individuals Am J Physiol Heart Circ Physiol, January 1, 2007; 292(1): H304 - H310. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. S. Reed, N. Charkoudian, A. Vella, P. Shah, R. A. Rizza, and M. J. Joyner Forearm vascular control during acute hyperglycemia in healthy humans Am J Physiol Endocrinol Metab, March 1, 2004; 286(3): E472 - E480. [Abstract] [Full Text]
|
|
|
|
 |
|
 N. Charkoudian, A. Vella, A. S. Reed, C. T. Minson, P. Shah, R. A. Rizza, and M. J. Joyner Cutaneous vascular function during acute hyperglycemia in healthy young adults J Appl Physiol, October 1, 2002; 93(4): 1243 - 1250. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. A. EARLE, S. MEHROTRA, R. N. DALTON, E. DENVER, and R. SWAMINATHAN Defective Nitric Oxide Production and Functional Renal Reserve in Patients with Type 2 Diabetes Who Have Microalbuminuria of African and Asian Compared with White Origin J. Am. Soc. Nephrol., October 1, 2001; 12(10): 2125 - 2130. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. M. Fitzgerald and M. W. Brands Nitric oxide may be required to prevent hypertension at the onset of diabetes Am J Physiol Endocrinol Metab, October 1, 2000; 279(4): E762 - E768. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Ding, N. D. Vaziri, R. Coulson, V. S. Kamanna, and D. D. Roh Effects of simulated hyperglycemia, insulin, and glucagon on endothelial nitric oxide synthase expression Am J Physiol Endocrinol Metab, July 1, 2000; 279(1): E11 - E17. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. W. Brands and S. M. Fitzgerald Acute Endothelium-Mediated Vasodilation Is Not Impaired at the Onset of Diabetes Hypertension, September 1, 1998; 32(3): 541 - 547. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. B. Williams, A. B. Goldfine, F. K. Timimi, H. H. Ting, M.-A. Roddy, D. C. Simonson, and M. A. Creager Acute Hyperglycemia Attenuates Endothelium-Dependent Vasodilation in Humans In Vivo Circulation, May 5, 1998; 97(17): 1695 - 1701. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. M. Pieper Review of Alterations in Endothelial Nitric Oxide Production in Diabetes : Protective Role of Arginine on Endothelial Dysfunction Hypertension, May 1, 1998; 31(5): 1047 - 1060. [Full Text] [PDF]
|
|
|
|
 |
|
 F.C Huvers, P.W de Leeuw, C.H.A de Haan, A.J.H.M Houben, C Buijs, and N.C Schaper The enhanced pressor response in type 2 diabetes is not based upon a generalized increase in vascular responsiveness Cardiovasc Res, April 1, 1998; 38(1): 206 - 214. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
