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Am J Physiol Heart Circ Physiol 271: H969-H976, 1996;
0363-6135/96 $5.00
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AJP - Heart and Circulatory Physiology, Vol 271, Issue 3 969-H976, Copyright © 1996 by American Physiological Society

ARTICLES

Interaction between sympathetic and sensory nerves in rat small arteries: involvement of nitric oxide

A. Ahluwalia and P. Vallance
Department of Pharmacology and Clinical Pharmacology, St. George's Hospital Medical School, Tooting, United Kingdom.

The aim of this study was to determine the effects of C-fiber activation on the reactivity of resistance arteries. Rat small mesenteric arteries were mounted in a tension myograph. Electrical field stimulation (EFS) of vessels produced brief contractions that were abolished by tetrodotoxin (1 microM, n = 4) or guanethidine (5 microM, n = 4). Capsaicin caused concentration-related attenuation of the EFS contraction [giving EFS responses of 61.7 +/- 4.3, 39.8 +/- 5.9, and 14.0 +/- 3.9% (n = 13-16) of control EFS contraction in the presence of 1, 3, and 10 microM capsaicin, respectively]. This effect was attenuated by the calcitonin gene-related peptide (CGRP) receptor antagonist CGRP-(8-37) (1 microM, n = 4, P < 0.05), NG-monomethyl-L-arginine (L-NMMA; 100 microM, n = 4, P < 0.01), or endothelial denudation (n = 5, P < 0.001). CGRP concentration-dependent inhibited (n = 5) EFS contraction, but this was unaffected by (L-NMMA (100 microM, n = 4). Capsaicin also relaxed preconstricted vessels (U-46619). This response was attenuated by ruthenium red (30 microM, n = 5, concentration ratio of 3.5 +/- 1.0) and CGRP-(8-37) (1 microM, n = 5, P < 0.05), while L-NMMA (100 microM, n = 6) showed variable effects, and denudation had no effect. These results show directly for the first time responses to activation of capsaicin-sensitive C fibers which modulate reactivity and the responses to sympathetic stimulation of isolated rat small mesenteric arteries, with the latter being an endothelial nitric oxide-dependent effect.


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J. A. Brock, M. Yeoh, and E. M. McLachlan
Enhanced neurally evoked responses and inhibition of norepinephrine reuptake in rat mesenteric arteries after spinal transection
Am J Physiol Heart Circ Physiol, January 1, 2006; 290(1): H398 - H405.
[Abstract] [Full Text] [PDF]


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