AJP - Heart and Circulatory Physiology, Vol 273, Issue 1 38-H43, Copyright © 1997 by American Physiological Society

ARTICLES

Inhibition of NO synthesis does not potentiate dynamic cardiovascular response to sympathetic nerve activity

H. Miyano, T. Kawada, M. Sugimachi, T. Shishido, T. Sato, J. Alexander Jr and K. Sunagawa
Department of Cardiovascular Dynamics, National Cardiovascular Center Research Institute, Osaka, Japan.

We examined whether the inhibition of nitric oxide (NO) synthesis potentiates the dynamic sympathetic regulation of the cardiovascular system through the baroreflex. In anesthetized rabbits, we imposed random pressure perturbations on the isolated carotid sinuses to evoke random changes in sympathetic nerve activity (SNA). We estimated the transfer functions from SNA to both aortic pressure (AoP) and heart rate (HR). The inhibition of NO synthesis by NG-monomethyl-L-arginine (L-NMMA, 40 mg/ kg) altered neither the transfer function from SNA to AoP nor that from SNA to HR. In contrast, sodium nitroprusside (3-6 micrograms.kg-1.min-1) significantly decreased the steady-state gain (40.3 +/- 11.7% of the control, P < 0.05) of the transfer function from SNA to AoP without affecting the HR responses. We conclude that the basal release of NO may have a role in the tonic blood pressure regulation, whereas it may not be involved in the dynamic sympathetic regulation of AoP or HR through the baroreflex.

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