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Am J Physiol Heart Circ Physiol 273: H511-H525, 1997;
0363-6135/97 $5.00
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AJP - Heart and Circulatory Physiology, Vol 273, Issue 2 511-H525, Copyright © 1997 by American Physiological Society

ARTICLES

Structure and function of cardiac sodium and potassium channels

D. M. Roden and A. L. George Jr
Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-6602, USA.

The application of patch-clamp and molecular approaches has resulted in an increasingly refined understanding of the molecular entities underlying cardiac sodium and potassium currents. The sodium current results from expression of a single large alpha-subunit, whereas multiple potassium currents and potassium channel alpha-subunits have been identified. Recapitulation of some ion currents in heterologous expression systems requires not only expression of alpha-subunits but also ancillary (beta) subunits. Domains common to functions such as activation, inactivation, and drug block are now being identified in alpha- and beta-gene products. Variability in the expression or function of individual ion-channel genes is an increasingly recognized source of variability in the ion currents recorded in heart cells under physiological conditions (e.g. during development) as well as in disease.


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