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Am J Physiol Heart Circ Physiol 273: H1754-H1760, 1997;
0363-6135/97 $5.00
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Vol. 273, Issue 4, H1754-H1760, October 1997

Incidence of arrhythmias and heart rate variability in wild-type rats exposed to social stress

Andrea Sgoifo, Sietse F. De Boer, Christel Westenbroek, Frans W. Maes, Hans Beldhuis, Takanori Suzuki, and Jaap M. Koolhaas

Center for Behavioral and Cognitive Neurosciences, Department of Animal Physiology, University of Groningen, 9750 AA Haren, The Netherlands

Psychological stressors of different natures can induce different shifts of autonomic control on cardiac electrical activity, with either a sympathetic or a parasympathetic prevalence. Arrhythmia occurrence, R-R interval variability, and plasma catecholamine elevations were measured in male wild-type rats exposed to either a social stressor (defeat) or a nonsocial challenge (restraint). Electrocardiograms were telemetrically recorded, and blood samples were withdrawn through jugular vein catheters from normal, freely moving animals. Defeat produced a much higher incidence of arrhythmias (mostly ventricular premature beats), which were mainly observed in the 60-s time periods after attacks. The social challenge also induced a much stronger reduction of average R-R interval, a lower R-R interval variability (as estimated by the time-domain parameters standard deviation of mean R-R interval duration, coefficient of variance, and root mean square of successive differences in R-R interval duration), and higher elevations of venous plasma catecholamines compared with restraint. These autonomic and/or neuroendocrine data indicate that a social stressor such as defeat is characterized by both a higher sympathetic activation and a lower parasympathetic antagonism compared with a nonsocial restraint challenge, which results in a higher risk for ventricular arrhythmias.

telemetry electrocardiogram; autonomic nervous system; catecholamines; defeat; restraint


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