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Am J Physiol Heart Circ Physiol 273: H1787-H1793, 1997;
0363-6135/97 $5.00
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Vol. 273, Issue 4, H1787-H1793, October 1997

Cardiovascular responses to dynamic exercise with acute anemia in humans

Maria D. Koskolou, Robert C. Roach, José A. L. Calbet, Göran Rådegran, and Bengt Saltin

The Copenhagen Muscle Research Center, Rigshospitalet, DK-2200 Copenhagen, Denmark

We hypothesized that reducing arterial O2 content (CaO2) by lowering the hemoglobin concentration ([Hb]) would result in a higher blood flow, as observed with a low PO2, and maintenance of O2 delivery. Seven young healthy men were studied twice, at rest and during two-legged submaximal and peak dynamic knee extensor exercise in a control condition (mean control [Hb] 144 g/l) and after 1-1.5 liters of whole blood had been withdrawn and replaced with albumin {mean drop in [Hb] 29 g/l (range 19-38 g/l); low [Hb]}. Limb blood flow (LBF) was higher (P < 0.01) with low [Hb] during submaximal exercise (i.e., at 30 W, LBF was 2.5 ± 0.1 and 3.0 ± 0.1 l/min for control [Hb] and low [Hb], respectively; P < 0.01), resulting in a maintained O2 delivery and O2 uptake for a given workload. However, at peak exercise, LBF was unaltered (6.5 ± 0.4 and 6.6 ± 0.6 l/min for control [Hb] and low [Hb], respectively), which resulted in an 18% reduction in O2 delivery (P < 0.01). This occurred despite peak cardiac output in neither condition reaching >75% of maximal cardiac output (~26 l/min). It is concluded that a low CaO2 induces an elevation in submaximal muscle blood flow and that O2 delivery to contracting muscles is tightly regulated.

red blood cell; hemoglobin; skeletal muscle; vasodilatation; cardiac output


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