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Am J Physiol Heart Circ Physiol 273: H1909-H1919, 1997;
0363-6135/97 $5.00
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Vol. 273, Issue 4, H1909-H1919, October 1997

Pontine neurons are elements of the network responsible for the 10-Hz rhythm in sympathetic nerve discharge

Susan M. Barman, Heather L. Kitchens, Aaron B. Leckow, and Gerard L. Gebber

Departments of Pharmacology and Toxicology and of Physiology, Michigan State University, East Lansing, Michigan 48824

The current study was designed to test the hypothesis that pontine neurons are elements of the network responsible for the 10-Hz rhythm in sympathetic nerve discharge (SND). The first series of experiments tested whether chemical inactivation of neurons in the rostral dorsolateral pons (RDLP) or caudal ventrolateral pons (CVLP) affected inferior cardiac postganglionic SND of urethan-anesthetized cats. Muscimol microinjections into either region eliminated the 10-Hz rhythm in SND, supporting the view that pontine neurons are involved in the expression of this rhythm. Additional experiments were designed to determine if pontine neurons have activity correlated to the 10-Hz rhythm in SND or whether they merely provide a tonic (nonrhythmic) driving input to the rhythm generator. Coherence analysis revealed that local field potentials recorded from the RDLP or CVLP had a 10-Hz component that was significantly correlated to SND. Also, spike-triggered averaging and coherence analysis showed that the naturally occurring discharges of individual RDLP or CVLP neurons were correlated to the 10-Hz rhythm in SND. Taken together, these data support the hypothesis that RDLP and CVLP neurons are essential for the expression of the 10-Hz rhythm in SND and that they are elements of or receive input from the rhythm generator.

blood pressure; caudal ventrolateral pons; frequency-domain analyses; muscimol microinjections; rostral dorsolateral pons; spike-triggered averaging


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