AJP - Heart BIOPAC complete lab solutions
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Heart Circ Physiol 273: H1909-H1919, 1997;
0363-6135/97 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Barman, S. M.
Right arrow Articles by Gebber, G. L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Barman, S. M.
Right arrow Articles by Gebber, G. L.
Vol. 273, Issue 4, H1909-H1919, October 1997

Pontine neurons are elements of the network responsible for the 10-Hz rhythm in sympathetic nerve discharge

Susan M. Barman, Heather L. Kitchens, Aaron B. Leckow, and Gerard L. Gebber

Departments of Pharmacology and Toxicology and of Physiology, Michigan State University, East Lansing, Michigan 48824

The current study was designed to test the hypothesis that pontine neurons are elements of the network responsible for the 10-Hz rhythm in sympathetic nerve discharge (SND). The first series of experiments tested whether chemical inactivation of neurons in the rostral dorsolateral pons (RDLP) or caudal ventrolateral pons (CVLP) affected inferior cardiac postganglionic SND of urethan-anesthetized cats. Muscimol microinjections into either region eliminated the 10-Hz rhythm in SND, supporting the view that pontine neurons are involved in the expression of this rhythm. Additional experiments were designed to determine if pontine neurons have activity correlated to the 10-Hz rhythm in SND or whether they merely provide a tonic (nonrhythmic) driving input to the rhythm generator. Coherence analysis revealed that local field potentials recorded from the RDLP or CVLP had a 10-Hz component that was significantly correlated to SND. Also, spike-triggered averaging and coherence analysis showed that the naturally occurring discharges of individual RDLP or CVLP neurons were correlated to the 10-Hz rhythm in SND. Taken together, these data support the hypothesis that RDLP and CVLP neurons are essential for the expression of the 10-Hz rhythm in SND and that they are elements of or receive input from the rhythm generator.

blood pressure; caudal ventrolateral pons; frequency-domain analyses; muscimol microinjections; rostral dorsolateral pons; spike-triggered averaging


This article has been cited by other articles:


Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
S. M. Barman and G. L. Gebber
The posterior vermis of the cerebellum selectively inhibits 10-Hz sympathetic nerve discharge in anesthetized cats
Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2009; 297(1): R210 - R217.
[Abstract] [Full Text] [PDF]

Home page
 J Biol RhythmsHome page
S. M. Barman and G. L. Gebber
"Rapid" Rhythmic Discharges of Sympathetic Nerves: Sources, Mechanisms of Generation, and Physiological Relevance
J Biol Rhythms, October 1, 2000; 15(5): 365 - 379.
[Abstract] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
H. S. Orer, S. M. Barman, G. L. Gebber, and S. M. Sykes
Medullary lateral tegmental field: an important synaptic relay in the baroreceptor reflex pathway of the cat
Am J Physiol Regulatory Integrative Comp Physiol, November 1, 1999; 277(5): R1462 - R1475.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
S. M. Barman, G. L. Gebber, and H. Kitchens
Rostral dorsolateral pontine neurons with sympathetic nerve-related activity
Am J Physiol Heart Circ Physiol, February 1, 1999; 276(2): H401 - H412.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
S. M. Barman and G. L. Gebber
Classification of Caudal Ventrolateral Pontine Neurons With Sympathetic Nerve-Related Activity
J Neurophysiol, November 1, 1998; 80(5): 2433 - 2445.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online