| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Department of Pharmacological and Physiological Science, Saint Louis University Health Sciences Center, St. Louis, Missouri 63104
Neuropeptide Y (NPY) is a vasoconstrictor peptide and a cotransmitter with norepinephrine (NE) in sympathetic nerve terminals and is thought to be involved in sympathetic nerve stimulation (SNS)-induced vasoconstriction. Using BIBP-3226, a Y1 receptor selective antagonist, we examined this hypothesis in the isolated and perfused mesenteric vascular bed. SNS produced a frequency-dependent increase in perfusion pressure and concomitant overflow of NPY immunoreactivity in the perfusate. [Leu31,Pro34]NPY potentiated NE-induced and ATP-induced vasoconstriction, indicating the presence and biological action of Y1 receptors in this vascular bed. The potentiation effect of [Leu31,Pro34]NPY of the increase in perfusion pressure by NE, ATP, or SNS was prevented by BIBP-3226. In addition, SNS-induced vasoconstriction at both high and low frequencies was significantly attenuated by BIBP-3226 at a concentration that completely blocked the [Leu31,Pro34]NPY-induced potentiation of the NE- or ATP-induced vasoconstrictor effect. These results suggest that ~30% of vasoconstriction produced by SNS depends on NPY in the mesenteric vascular bed.
BIBP-3226; neuropeptide Y release; adenosine 5'-triphosphate; mesenteric vascular bed; rat
This article has been cited by other articles:
|
|
 |
|
  G. J. Hodges, W. A. Kosiba, K. Zhao, and J. M. Johnson The involvement of norepinephrine, neuropeptide Y, and nitric oxide in the cutaneous vasodilator response to local heating in humans J Appl Physiol, July 1, 2008; 105(1): 233 - 240. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. H. Damon TH and NPY in sympathetic neurovascular cultures: role of LIF and NT-3 Am J Physiol Cell Physiol, January 1, 2008; 294(1): C306 - C312. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Igosheva, P. D. Taylor, L. Poston, and V. Glover Prenatal stress in the rat results in increased blood pressure responsiveness to stress and enhanced arterial reactivity to neuropeptide Y in adulthood J. Physiol., July 15, 2007; 582(2): 665 - 674. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. J. W. Fletcher, D. S. Gardner, C. M. B. Edwards, A. L. Fowden, and D. A. Giussani Development of the ovine fetal cardiovascular defense to hypoxemia towards full term Am J Physiol Heart Circ Physiol, December 1, 2006; 291(6): H3023 - H3034. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Bradley, A. Law, D. Bell, and C. D. Johnson Effects of varying impulse number on cotransmitter contributions to sympathetic vasoconstriction in rat tail artery Am J Physiol Heart Circ Physiol, June 1, 2003; 284(6): H2007 - H2014. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C.-s. Liang, A. Yatani, Y. Himura, M. Kashiki, and S. Y. Stevens Desipramine attenuates loss of cardiac sympathetic neurotransmitters produced by congestive heart failure and NE infusion Am J Physiol Heart Circ Physiol, May 1, 2003; 284(5): H1729 - H1736. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. O. Mundinger and G. J. Taborsky Jr. Differential action of hepatic sympathetic neuropeptides: metabolic action of galanin, vascular action of NPY Am J Physiol Endocrinol Metab, March 1, 2000; 278(3): E390 - E397. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. OBERHAUSER, O. VONEND, and L. C. RUMP Neuropeptide Y and ATP Interact to Control Renovascular Resistance in the Rat J. Am. Soc. Nephrol., June 1, 1999; 10(6): 1179 - 1185. [Abstract] [Full Text]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
