AJP - Heart Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Heart Circ Physiol 274: H430-H440, 1998;
0363-6135/98 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Pál, M.
Right arrow Articles by Johnson, P. C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Pál, M.
Right arrow Articles by Johnson, P. C.
Vol. 274, Issue 2, H430-H440, February 1998

Capillary blood flow and tissue metabolism in skeletal muscle during sympathetic trunk stimulation

Miklós Pál, András Tóth, Peipei Ping, and Paul C. Johnson

Department of Physiology, University of Arizona College of Medicine, Tucson, Arizona 85724

NADH fluorescence at tissue sites 15-20 µm in diameter and red blood cell velocity in adjacent capillaries were measured in resting sartorius muscle of the anesthetized cat during a 3-min period of sympathetic trunk stimulation. At stimulation frequencies of 2 and 4 Hz, red blood cell velocity fell briefly to 30-40% of control and then returned to ~75% of control values (vascular escape). No change in NADH fluorescence was observed. With stimulus frequencies of 6-12 Hz, flow reduction was greater and led to an increase in fluorescence when the flow reduction was >50% and was sustained for >30 s. NADH changes were more pronounced at tissue sites near venous capillaries than at sites near arterial capillaries. Hyperemia ensued after the end of sympathetic stimulation only when NADH fluorescence rose during stimulation. Resting blood flow in this muscle appears to be well above the minimum required to support oxidative metabolism. A shift to anaerobic metabolism does not appear to cause vascular escape during sympathetic stimulation but appears to be required for poststimulation hyperemia. These observations suggest that two separate oxygen-dependent mechanisms elicit vasodilation during and after sympathetic trunk stimulation.

blood flow regulation; red blood cell velocity; reduced nicotinamide adenine dinucleotide; anaerobic metabolism; skeletal muscle metabolism


This article has been cited by other articles:


Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
A. Toth, M. Pal, M. Intaglietta, and P. C. Johnson
Contribution of anaerobic metabolism to reactive hyperemia in skeletal muscle
Am J Physiol Heart Circ Physiol, June 1, 2007; 292(6): H2643 - H2653.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
A. Mayevsky and G. G. Rogatsky
Mitochondrial function in vivo evaluated by NADH fluorescence: from animal models to human studies
Am J Physiol Cell Physiol, February 1, 2007; 292(2): C615 - C640.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
P. C. Johnson, K. Vandegriff, A. G. Tsai, and M. Intaglietta
Effect of acute hypoxia on microcirculatory and tissue oxygen levels in rat cremaster muscle
J Appl Physiol, April 1, 2005; 98(4): 1177 - 1184.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
Z. Ming, C. Han, and W. W. Lautt
Nitric oxide mediates hepatic arterial vascular escape from norepinephrine-induced constriction
Am J Physiol Gastrointest Liver Physiol, December 1, 1999; 277(6): G1200 - G1206.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
K. N. Richmond, R. D. Shonat, R. M. Lynch, and P. C. Johnson
Critical PO2 of skeletal muscle in vivo
Am J Physiol Heart Circ Physiol, November 1, 1999; 277(5): H1831 - H1840.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online