| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Institut National de la Santé et de la Recherche Médicale, U451-Loa-Ensta-Ecole Polytechnique, 91125 Palaiseau Cédex; Service de Physiologie Cardio-Respiratoire, Université de Paris XI, Hôpital de Bicêtre, 94275 Le Kremlin Bicêtre; and Service de Cardiologie, Hôpital Antoine-Béclère, 92141 Clamart, France
On the basis of
the windkessel model, the stroke volume-to-aortic pulse
pressure ratio (SV/PP) has been proposed as an estimate of total
arterial compliance, but recent studies have questioned this
approximation. Aortic pressure was obtained at rest in 31 adults
undergoing cardiac catheterization (47 ± 14 yr): controls (n = 7), patients with dilated
cardiomyopathy (n = 10), and patients with other cardiac diseases (n = 14).
We calculated PP, mean aortic pressure (MAoP), heart period
(T), SV (thermodilution cardiac output/heart rate), total peripheral resistance
(R), total arterial compliance
estimated by area method
(Carea), and
the time constant of aortic pressure decay in diastole
(RCarea). In
the overall population (n = 31), there
was no significant difference between SV/PP and
Carea. SV/PP was
linearly related to
Carea (SV/PP = 0.99Carea + 0.05;
r = 0.98;
P < 0.001); the slope and intercept did not differ from unity and zero, respectively. Similar results were
obtained in the three subgroups. These results implied that PP/MAoP and
T/RCarea
were proportionally related
(T/RCarea = 1.18PP/MAoP 
0.07; r = 0.96;
P < 0.001). We conclude that for
humans at rest 1) SV/PP gave a
reliable estimate of
Carea, and
2)
T normalized by the time constant of
aortic pressure decay in diastole was proportionally related to
PP/MAoP. This last relationship could be considered an aspect of the
coupling between the left ventricle and its load.
heart period; ventricular-arterial coupling; wave reflection
This article has been cited by other articles:
|
|
 |
|
  J. E. Sharman, J. Brown, D. J. Holland, G. Macdonald, K. Kostner, and T. H. Marwick Influence of Altered Blood Rheology on Ventricular-Vascular Response to Exercise Hypertension, November 1, 2009; 54(5): 1092 - 1098. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Zamir, R. Goswami, D. Salzer, and J. K. Shoemaker Cardiovascular Control: Role of vascular bed compliance in vasomotor control in human skeletal muscle Exp Physiol, September 1, 2007; 92(5): 841 - 848. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Shibata, R. Zhang, J. Hastings, Q. Fu, K. Okazaki, K.-i. Iwasaki, and B. D. Levine Cascade model of ventricular-arterial coupling and arterial-cardiac baroreflex function for cardiovascular variability in humans Am J Physiol Heart Circ Physiol, November 1, 2006; 291(5): H2142 - H2151. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Briand, J. G. Dumesnil, L. Kadem, A. G. Tongue, R. Rieu, D. Garcia, and P. Pibarot Reduced Systemic Arterial Compliance Impacts Significantly on Left Ventricular Afterload and Function in Aortic Stenosis: Implications for Diagnosis and Treatment J. Am. Coll. Cardiol., July 19, 2005; 46(2): 291 - 298. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Garcia, P. J. C. Barenbrug, P. Pibarot, A. L. A. J. Dekker, F. H. van der Veen, J. G. Maessen, J. G. Dumesnil, and L.-G. Durand A ventricular-vascular coupling model in presence of aortic stenosis Am J Physiol Heart Circ Physiol, April 1, 2005; 288(4): H1874 - H1884. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. O. Debrah, K. P. Conrad, L. A. Danielson, and S. G. Shroff Effects of relaxin on systemic arterial hemodynamics and mechanical properties in conscious rats: sex dependency and dose response J Appl Physiol, March 1, 2005; 98(3): 1013 - 1020. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L Kadem, J G Dumesnil, R Rieu, L-G Durand, D Garcia, and P Pibarot Impact of systemic hypertension on the assessment of aortic stenosis Heart, March 1, 2005; 91(3): 354 - 361. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Segers, D. Georgakopoulos, M. Afanasyeva, H. C. Champion, D. P. Judge, H. D. Millar, P. Verdonck, D. A. Kass, N. Stergiopulos, and N. Westerhof Conductance catheter-based assessment of arterial input impedance, arterial function, and ventricular-vascular interaction in mice Am J Physiol Heart Circ Physiol, March 1, 2005; 288(3): H1157 - H1164. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. R. Rinder, R. J. Spina, L. R. Peterson, C. J. Koenig, C. R. Florence, and A. A. Ehsani Comparison of effects of exercise and diuretic on left ventricular geometry, mass, and insulin resistance in older hypertensive adults Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2004; 287(2): R360 - R368. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P.-S. Tsai, C. B. Yucha, W. W. Nichols, and H. Yarandi Hemodynamics and Arterial Properties in Response to Mental Stress in Individuals with Mild Hypertension Psychosom Med, July 1, 2003; 65(4): 613 - 619. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Michard and J.-L. Teboul Predicting Fluid Responsiveness in ICU Patients* : A Critical Analysis of the Evidence Chest, June 1, 2002; 121(6): 2000 - 2008. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Boulain, J.-M. Achard, J.-L. Teboul, C. Richard, D. Perrotin, and G. Ginies Changes in BP Induced by Passive Leg Raising Predict Response to Fluid Loading in Critically Ill Patients* Chest, April 1, 2002; 121(4): 1245 - 1252. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Chemla, E. Aptecar, J.-L. Hebert, C. Coirault, D. Loisance, Y. Lecarpentier, and A. Nitenberg Short-term variability of pulse pressure and systolic and diastolic time in heart transplant recipients Am J Physiol Heart Circ Physiol, July 1, 2000; 279(1): H122 - H129. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Segers, S. Brimioulle, N. Stergiopulos, N. Westerhof, R. Naeije, M. Maggiorini, and P. Verdonck Pulmonary arterial compliance in dogs and pigs: the three-element windkessel model revisited Am J Physiol Heart Circ Physiol, August 1, 1999; 277(2): H725 - H731. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Stergiopulos, P. Segers, and N. Westerhof Use of pulse pressure method for estimating total arterial compliance in vivo Am J Physiol Heart Circ Physiol, February 1, 1999; 276(2): H424 - H428. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-L. Hebert, C. Coirault, K. Zamani, G. Fontaine, Y. Lecarpentier, and D. Chemla Pulse pressure response to the strain of the Valsalva maneuver in humans with preserved systolic function J Appl Physiol, September 1, 1998; 85(3): 817 - 823. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Segers, N. Stergiopulos, and N. Westerhof Relation of effective arterial elastance to arterial system properties Am J Physiol Heart Circ Physiol, March 1, 2002; 282(3): H1041 - H1046. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. A. Kass, E. P. Shapiro, M. Kawaguchi, A. R. Capriotti, A. Scuteri, R. C. deGroof, and E. G. Lakatta Improved Arterial Compliance by a Novel Advanced Glycation End-Product Crosslink Breaker Circulation, September 25, 2001; 104(13): 1464 - 1470. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
