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Am J Physiol Heart Circ Physiol 274: H520-H528, 1998;
0363-6135/98 $5.00
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Vol. 274, Issue 2, H520-H528, February 1998

Hemodilution and hyperoxia locally change distribution of regional pulmonary perfusion in dogs

Martin Kleen1,2, Oliver Habler1,2, Jörg Hutter1, Gregor Kemming2, Armin Podtschaske1, Matthias Tiede1, Martin Welte1,2, Peter E. Keipert3, Sanjay Batra3, N. Simon Faithfull3, Carlos Corso1, Bernhard Zwissler2, and Konrad Messmer1

1 Institute for Surgical Research and 2 Institute of Anesthesiology, Klinikum Grosshadern, University of Munich, 81366 Munich, Germany; and 3 Alliance Pharmaceutical Corporation, San Diego, California

In seven anesthetized dogs, the effects of acute normovolemic hemodilution (ANH) to a hematocrit of 20 and 8% and the effects of hyperoxic ventilation (100% oxygen) on distribution of regional pulmonary blood flow (rPBF; radioactive microspheres) were investigated. Normovolemia was monitored with blood volume measurements (indocyanine green dilution kinetics). Before ANH, fractal dimension (D) of rPBF in the whole lung was 1.19 ± 0.09 (mean ± SD). Spatial correlation (rho ) of rPBF in the whole lung was 0.6 ± 0.08. D is a resolution-independent measure for global rPBF distribution, and rho  is the averaged flow relationship of directly neighboring lung samples. With regard to the entire lung, neither ANH nor hyperoxia changed D or rho . With regard to horizontal, isogravitational planes, ANH induced opposite changes of rPBF heterogeneity depending on the vertical location of the plane and the parameter used. In ventral planes, a change in relative dispersion (SD/mean) indicated decreased homogeneity. However, rho  suggested more homogeneous perfusion. Hyperoxia restored baseline rPBF distribution. Our data suggest that ANH causes different alterations of heterogeneity of rPBF depending on location within the lung.

fractals; spatial correlation; spatial heterogeneity


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S. Deem, R. G. Hedges, S. McKinney, N. L. Polissar, M. K. Alberts, and E. R. Swenson
Mechanisms of improvement in pulmonary gas exchange during isovolemic hemodilution
J Appl Physiol, July 1, 1999; 87(1): 132 - 141.
[Abstract] [Full Text] [PDF]


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