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Departments of 1 Radiology and 2 Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75235
Transgenic mice with a dysfunctional guanylyl
cyclase A gene (GCA 
/) are unable to transduce the
signals from atrial naturetic peptide and develop hypertension and
cardiac hypertrophy. Magnetic resonance imaging (MRI) was performed to
assess cardiac hypertrophy in these animals, using wild-type siblings
as controls. Anesthetized mice were studied by gated multislice,
multiphase cine MRI at 1.5 T. Simpson's rule was used to estimate left
ventricle (LV) mass and volumes from short-axis images. Correlation
between LV mass evaluated by MRI and at necropsy was excellent, with
LVnecropsy = 1.04 × LVMRI + 4.69 mg
(r2 = 0.95). By
MRI, GCA / LV mass was significantly different when
compared with isogenic controls [GCA /, 226 ± 43 mg (n = 14) vs. controls, 156 ± 14 mg (n = 10);
P < 0.0001]. LV volumes and
ejection fraction in the two groups were not significantly different.
MRI provides an accurate means for the noninvasive assessment of murine
cardiac phenotype and may be useful in following the effects of genetic
modification.
myocardial hypertrophy; transgenic models; left ventricular mass
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