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Am J Physiol Heart Circ Physiol 274: H1066-H1074, 1998;
0363-6135/98 $5.00
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Vol. 274, Issue 4, H1066-H1074, April 1998

Hemodynamic effects of L-glutamate in NTS of conscious rats: a possible role of vascular nitrosyl factors

Eduardo Colombari1, Robin L. Davisson2, Richard A. Shaffer2, William T. Talman1, and Stephen J. Lewis2

The Cardiovascular Center and Departments of 1 Neurology and 2 Pharmacology, The University of Iowa College of Medicine and Department of Veterans Affairs Medical Center, Iowa City, Iowa 52242

This study examined peripheral mechanisms responsible for changes in mean arterial blood pressure, heart rate, and renal, mesenteric, and hindquarter vascular resistances produced by microinjections of L-glutamate (L-Glu) into the nucleus tractus solitarii (NTS) of conscious rats. Microinjection of L-Glu produced an initial pressor response, bradycardia, and vasoconstriction in each vascular bed. Subsequent hindquarter vasodilation was observed. After prazosin was administered, L-Glu produced initial hypotension that was probably due to reduced cardiac output. This hypotension was followed by hindquarter vasodilation. Inhibition of nitric oxide synthesis did not affect the initial hypotension or bradycardia in rats treated with prazosin, but the first microinjection of L-Glu after administration of prazosin and NG-nitro-L-arginine methyl ester (L-NAME) produced significantly greater hindquarter vasodilation than after administration of prazosin alone. Second and third microinjections of L-Glu produced significantly smaller hindquarter vasodilation. We conclude that 1) hemodynamic effects produced by microinjection of L-Glu into the NTS of conscious rats involves activation of the sympathetic nervous system and 2) release of preformed nitrosyl factors may mediate vasodilation in the hindquarter vascular bed.

autonomic control; hemodynamics; nitric oxide; excitatory amino acids


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