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Am J Physiol Heart Circ Physiol 274: H1106-H1112, 1998;
0363-6135/98 $5.00
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Vol. 274, Issue 4, H1106-H1112, April 1998

KATP channels are common mediators of ischemic and calcium preconditioning in rabbits

Ichiro Kouchi, Tomoyuki Murakami, Ryuzo Nawada, Masaharu Akao, and Shigetake Sasayama

Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Kyoto 606-01, Japan

Calcium preconditioning (CPC), like ischemic preconditioning (IPC), reduces myocardial infarct size in dogs and rats. ATP-sensitive potassium (KATP) channels induce cardioprotection of IPC in these animals. To determine whether KATP channels mediate both IPC and CPC, pentobarbital sodium-anesthetized rabbits received 30 min of coronary artery occlusion followed by 180 min of reperfusion. IPC was elicited by 5 min of occlusion and 10 min of reperfusion, and CPC was elicited by two cycles of 5 min of calcium infusion with an interval period of 15 min. Infarct size expressed as a percentage of the area at risk was 38 ± 3% (mean ± SE) in controls. IPC, CPC, and pretreatment with a KATP channel opener, cromakalim, all reduced infarct size to 13 ± 2, 17 ± 2, and 12 ± 3%, respectively (P < 0.01 vs. controls). Glibenclamide, a KATP channel blocker administered 45 min (but not 20 min) before sustained ischemia, attenuated the effects of IPC and CPC (31 ± 4 and 41 ± 6%, respectively). Thus KATP channel activation appears to contribute to these two types of cardioprotection in rabbits.

infarct size; glibenclamide; cromakalim; verapamil


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