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Am J Physiol Heart Circ Physiol 274: H1163-H1173, 1998;
0363-6135/98 $5.00
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Vol. 274, Issue 4, H1163-H1173, April 1998

Conduction between isolated rabbit Purkinje and ventricular myocytes coupled by a variable resistance

Delilah J. Huelsing1,2, Kenneth W. Spitzer3, Jonathan M. Cordeiro4, and Andrew E. Pollard5

1 Department of Biomedical Engineering, Tulane University, New Orleans, Louisiana 70125; 2 Department of Medicine, Cardiac Rhythm Management Lab, and 5 Department of Biomedical Engineering, University of Alabama-Birmingham, Birmingham, Alabama 35294; 3 Nora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah School of Medicine, Salt Lake City, Utah 84112; and 4 Department of Physiology and Biophysics, University of Calgary School of Medicine, Calgary, Alberta T2N 4N1, Canada

Conduction at the Purkinje-ventricular junction (PVJ) demonstrates unidirectional block under both physiological and pathophysiological conditions. Although this block is typically attributed to multidimensional electrotonic interactions, we examined possible membrane-level contributions using single, isolated rabbit Purkinje (P) and ventricular (V) myocytes coupled by an electronic circuit. When we varied the junctional resistance (Rj) between paired V myocytes, conduction block occurred at lower Rj values during conduction from the smaller to larger myocyte (115 ± 59 MOmega ) than from the larger to smaller myocyte (201 ± 51 MOmega ). In Purkinje-ventricular myocyte pairs, however, block occurred at lower Rj values during P-to-V conduction (85 ± 39 MOmega ) than during V-to-P conduction (912 ± 175 MOmega ), although there was little difference in the mean cell size. Companion computer simulations, performed to examine how the early plateau currents affected conduction, showed that P-to-V block occurred at lower Rj values when the transient outward current was increased or the calcium current was decreased in the model P cell. These results suggest that intrinsic differences in phase 1 repolarization can contribute to unidirectional block at the PVJ.

action potential propagation; coupling-clamp circuit; membrane models; transient outward current; discontinuous conduction


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