AJP - Heart Ad Instruments
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Heart Circ Physiol 274: H1184-H1193, 1998;
0363-6135/98 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Rohrer, D. K.
Right arrow Articles by Bernstein, D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Rohrer, D. K.
Right arrow Articles by Bernstein, D.
Vol. 274, Issue 4, H1184-H1193, April 1998

Alterations in dynamic heart rate control in the beta 1-adrenergic receptor knockout mouse

Daniel K. Rohrer1,2, Eric H. Schauble1, Kavin H. Desai1, Brian K. Kobilka2, and Daniel Bernstein1

1 Division of Pediatric Cardiology, Department of Pediatrics, and 2 Howard Hughes Medical Institute, Stanford University, Stanford, California 94305

beta 1-Adrenergic receptors (beta 1-ARs) are key targets of sympathetic nervous system activity and play a major role in the beat-to-beat regulation of cardiac chronotropy and inotropy. We employed a beta 1-AR gene knockout model to test the hypothesis that beta 1-AR function is critical for maintenance of resting heart rate and baroreflex responsiveness and, on the basis of its important role in regulating chronotropy and inotropy, is also required for maximal exercise capacity. Using an awake unrestrained mouse model, we demonstrate that resting heart rate and blood pressure are normal in beta 1-AR knockouts and that the qualitative responses to baroreflex stimulation are intact. Chronotropic reserve in beta 1-AR knockouts is markedly limited, with peak heart rates ~200 beats/min less than wild types. During graded treadmill exercise, heart rate is significantly depressed in beta 1-AR knockouts at all work loads, but despite this limitation, there are no reductions in maximal exercise capacity or metabolic indexes. Thus, in mice, the beta 1-AR is not essential for either maintenance of resting heart rate or for maximally stressed cardiovascular performance.

gene disruption; exercise; baroreflex; autonomic; chronotropic


This article has been cited by other articles:


Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
S. J. Swoap, C. Li, J. Wess, A. D. Parsons, T. D. Williams, and J. M. Overton
Vagal tone dominates autonomic control of mouse heart rate at thermoneutrality
Am J Physiol Heart Circ Physiol, April 1, 2008; 294(4): H1581 - H1588.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
P. M. Ecker, C.-C. Lin, J. Powers, B. K. Kobilka, A. M. Dubin, and D. Bernstein
Effect of targeted deletions of {beta}1- and {beta}2-adrenergic-receptor subtypes on heart rate variability
Am J Physiol Heart Circ Physiol, January 1, 2006; 290(1): H192 - H199.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
D. Bernstein, G. Fajardo, M. Zhao, T. Urashima, J. Powers, G. Berry, and B. K. Kobilka
Differential cardioprotective/cardiotoxic effects mediated by {beta}-adrenergic receptor subtypes
Am J Physiol Heart Circ Physiol, December 1, 2005; 289(6): H2441 - H2449.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
R. Fazan Jr., M. de Oliveira, V. J. Dias da Silva, L. F. Joaquim, N. Montano, A. Porta, M. W. Chapleau, and H. C. Salgado
Frequency-dependent baroreflex modulation of blood pressure and heart rate variability in conscious mice
Am J Physiol Heart Circ Physiol, November 1, 2005; 289(5): H1968 - H1975.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
J. Powers and D. Bernstein
The mouse as a model of cardiovascular adaptations to microgravity
J Appl Physiol, November 1, 2004; 97(5): 1686 - 1692.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
B. J. A. Janssen, T. De Celle, J. J. M. Debets, A. E. Brouns, M. F. Callahan, and T. L. Smith
Effects of anesthetics on systemic hemodynamics in mice
Am J Physiol Heart Circ Physiol, October 1, 2004; 287(4): H1618 - H1624.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
S. Ishizaka, R. E. Sievers, B.-Q. Zhu, M. C. Rodrigo, S. Joho, E. Foster, P. C. Simpson, and W. Grossman
New technique for measurement of left ventricular pressure in conscious mice
Am J Physiol Heart Circ Physiol, March 1, 2004; 286(3): H1208 - H1215.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. GenomicsHome page
D. Bernstein
Exercise assessment of transgenic models of human cardiovascular disease
Physiol Genomics, May 13, 2003; 13(3): 217 - 226.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
P. C. Brum, J. Kosek, A. Patterson, D. Bernstein, and B. Kobilka
Abnormal cardiac function associated with sympathetic nervous system hyperactivity in mice
Am J Physiol Heart Circ Physiol, November 1, 2002; 283(5): H1838 - H1845.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
B. J. A. Janssen and J. F. M. Smits
Autonomic control of blood pressure in mice: basic physiology and effects of genetic modification
Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2002; 282(6): R1545 - R1564.
[Abstract] [Full Text] [PDF]

Home page
 Pharmacol. Rev.Home page
S. Guimaraes and D. Moura
Vascular Adrenoceptors: An Update
Pharmacol. Rev., June 1, 2001; 53(2): 319 - 356.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
H. Chen, Y. C. Zhang, D. Li, M. I. Phillips, P. Mehta, M. Shi, and J. L. Mehta
Protection against Myocardial Dysfunction Induced by Global Ischemia-Reperfusion by Antisense-Oligodeoxynucleotides Directed at beta 1-Adrenoceptor mRNA
J. Pharmacol. Exp. Ther., August 1, 2000; 294(2): 722 - 727.
[Abstract] [Full Text]

Home page
 Am. J. Physiol. Cell Physiol.Home page
S. Rao and A. S. Verkman
Analysis of organ physiology in transgenic mice
Am J Physiol Cell Physiol, July 1, 2000; 279(1): C1 - C18.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. GenomicsHome page
G. M. STORY, S. E. DICARLO, D. W. RODENBAUGH, D. E. DLUZEN, J. KUCERA, M. B. MARON, and J. M. WALRO
Inactivation of one copy of the mouse neurotrophin-3 gene induces cardiac sympathetic deficits
Physiol Genomics, April 27, 2000; 2(3): 129 - 136.
[Abstract] [Full Text] [PDF]

Home page
 Pharmacol. Rev.Home page
O.-E. Brodde and M. C. Michel
Adrenergic and Muscarinic Receptors in the Human Heart
Pharmacol. Rev., December 1, 1999; 51(4): 651 - 690.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
K. H. Desai, E. Schauble, W. Luo, E. Kranias, and D. Bernstein
Phospholamban deficiency does not compromise exercise capacity
Am J Physiol Heart Circ Physiol, April 1, 1999; 276(4): H1172 - H1177.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online