AJP - Heart AJP citation statistics
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Heart Circ Physiol 274: H1308-H1314, 1998;
0363-6135/98 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Laflamme, M. A.
Right arrow Articles by Becker, P. L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Laflamme, M. A.
Right arrow Articles by Becker, P. L.
Vol. 274, Issue 4, H1308-H1314, April 1998

Do beta 2-adrenergic receptors modulate Ca2+ in adult rat ventricular myocytes?

Michael A. Laflamme and Peter L. Becker

Department of Physiology, Emory University School of Medicine, Atlanta, Georgia 30322

We examined the role of beta 2-adrenergic receptors (ARs) in modulating calcium homeostasis in rat ventricular myocytes. Zinterol (10 µM), an agonist with a 25-fold greater affinity for beta 2-ARs over beta 1-ARs, modestly enhanced L-type calcium current (ICa) magnitude by ~30% and modestly accelerated the rate of Ca2+ concentration ([Ca2+]) decline (~35%) but had little effect on the magnitude of the [Ca2+] transient (a nonsignificant 6% increase). However, 1 µM of the highly selective beta 1-AR antagonist CGP-20712A completely blocked the ICa increase induced by 10 µM zinterol. Pretreatment of cells with pertussis toxin (PTX) did not alter ICa enhancement by 10 µM zinterol, although it did abolish the ability of acetylcholine to block the forskolin-induced enhancement of ICa. Zinterol (10 µM) approximately doubled adenosine 3',5'-cyclic monophosphate (cAMP) accumulation, although one-half of this increase was blocked by CGP-20712A. In contrast, 1 µM of the nonselective beta -agonist isoproterenol increased cAMP production 15-fold. Thus we found no evidence that activation of beta 2-ARs modulates calcium homeostasis in rat ventricular myocytes, even after treatment with PTX.

zinterol; CGP-20712A; calcium homeostasis; adenosine 3',5'-cyclic monophosphate


This article has been cited by other articles:


Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
L. P. Collis, S. Srivastava, W. A. Coetzee, and M. Artman
beta2-Adrenergic receptor agonists stimulate L-type calcium current independent of PKA in newborn rabbit ventricular myocytes
Am J Physiol Heart Circ Physiol, November 1, 2007; 293(5): H2826 - H2835.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
S. F. Steinberg
The Cellular Actions of {beta}-Adrenergic Receptor Agonists : Looking Beyond cAMP
Circ. Res., December 8, 2000; 87(12): 1079 - 1082.
[Full Text] [PDF]

Home page
 Circ. Res.Home page
T. J. Kamp and J. W. Hell
Regulation of Cardiac L-Type Calcium Channels by Protein Kinase A and Protein Kinase C
Circ. Res., December 8, 2000; 87(12): 1095 - 1102.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
Z. Nagykaldi, D. Kem, R. Lazzara, and B. Szabo
Conditioning of beta 1-adrenoceptor effect via beta 2-subtype on L-type Ca2+ current in canine ventricular myocytes
Am J Physiol Heart Circ Physiol, September 1, 2000; 279(3): H1329 - H1337.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
H. K. Ranu, J. C. W. Mak, P. J. Barnes, and S. E. Harding
Gi-dependent suppression of beta 1-adrenoceptor effects in ventricular myocytes from NE-treated guinea pigs
Am J Physiol Heart Circ Physiol, June 1, 2000; 278(6): H1807 - H1814.
[Abstract] [Full Text] [PDF]

Home page
 Pharmacol. Rev.Home page
O.-E. Brodde and M. C. Michel
Adrenergic and Muscarinic Receptors in the Human Heart
Pharmacol. Rev., December 1, 1999; 51(4): 651 - 690.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
S. F. Steinberg
The Molecular Basis for Distinct {beta}-Adrenergic Receptor Subtype Actions in Cardiomyocytes
Circ. Res., November 26, 1999; 85(11): 1101 - 1111.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online