AJP - Heart Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Heart Circ Physiol 274: H1423-H1428, 1998;
0363-6135/98 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Partovian, C.
Right arrow Articles by Safar, M. E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Partovian, C.
Right arrow Articles by Safar, M. E.
Vol. 274, Issue 5, H1423-H1428, May 1998

Effects of a chronic high-salt diet on large artery structure: role of endogenous bradykinin

Chohreh Partovian, Athanase Benetos, Jean-Pierre Pommiès, Willy Mischler, and Michel E. Safar

Department of Internal Medicine, Broussais Hospital, and Institut National de la Santé et de la Recherche Médicale U337, 75674 Paris Cedex 14, France

Bradykinin activity could explain the blood pressure increase during NaCl loading in hypertensive animals, but its contribution on vascular structure was not evaluated. We determined cardiac mass and large artery structure after a chronic, 4-mo, high-salt diet in combination with bradykinin B2-receptor blockade by Hoe-140. Four-week-old rats were divided into eight groups according to strain [spontaneously hypertensive rats (SHR) vs. Wistar-Kyoto (WKY) rats], diet (0.4 vs. 7% NaCl), and treatment (Hoe-140 vs. placebo). In WKY rats, a high-salt diet significantly increased intra-arterial blood pressure with minor changes in arterial structure independently of Hoe-140. In SHR, blood pressure remained stable but 1) the high-salt diet was significantly associated with cardiovascular hypertrophy and increased arterial elastin and collagen, and 2) Hoe-140 alone induced carotid hypertrophy. A high-salt diet plus Hoe-140 acted synergistically on carotid hypertrophy and elastin content in SHR, suggesting that the role of endogenous bradykinin on arterial structure was amplified in the presence of a high-salt diet.

spontaneously hypertensive rats


This article has been cited by other articles:


Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
J. Varagic, E. D. Frohlich, J. Diez, D. Susic, J. Ahn, A. Gonzalez, and B. Lopez
Myocardial fibrosis, impaired coronary hemodynamics, and biventricular dysfunction in salt-loaded SHR
Am J Physiol Heart Circ Physiol, April 1, 2006; 290(4): H1503 - H1509.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
M. M. Okamoto, D. H. Sumida, C. R. O. Carvalho, A. M. Vargas, J. C. Heimann, B. D'A. Schaan, and U. F. Machado
Changes in dietary sodium consumption modulate GLUT4 gene expression and early steps of insulin signaling
Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2004; 286(4): R779 - R785.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
M. E. Safar and P. Laurent
Pulse pressure and arterial stiffness in rats: comparison with humans
Am J Physiol Heart Circ Physiol, October 1, 2003; 285(4): H1363 - H1369.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online