AJP - Heart pressure measurements
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Heart Circ Physiol 274: H1569-H1573, 1998;
0363-6135/98 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Thompson, J. T.
Right arrow Articles by O'Brien, T. X.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Thompson, J. T.
Right arrow Articles by O'Brien, T. X.
Vol. 274, Issue 5, H1569-H1573, May 1998

Upregulation of the cardiac homeobox gene Nkx2-5 (CSX) in feline right ventricular pressure overload

Jerry T. Thompson, Mary S. Rackley, and Terrence X. O'Brien

Office of Research and Development, Ralph H. Johnson Department of Veterans Affairs Medical Center, and Cardiology Division, Department of Medicine, Medical University of South Carolina and the Gazes Cardiac Research Institute, Charleston, South Carolina 29425

The recent characterization of the cardiac-specific homeobox gene Nkx2-5 (or CSX) and its detection in normal adult heart tissue raises the possibility of a role in adult hypertrophy. Using pressure overload as a primary stimulus, we used a feline pulmonary artery banding model to produce right ventricular hypertrophy (RVH). Total RNA was hybridized to a full-length murine Nkx2-5 cDNA probe that contained the NK family homeodomain. Nkx2-5 mRNA levels increased 5.1-fold (P < 0.05) and 3.9-fold vs. the corresponding left ventricles at 2 and 7 days of RVH, respectively, during the period of maximal myocardial growth. By 2 wk, when the RVH response had been completed, Nkx2-5 mRNA levels were returning toward baseline. Hybridization with an Nkx2-5 probe not containing the NK homologous homeodomain demonstrated that upregulation was specific for the Nkx2-5 gene. Atrial natriuretic factor and alpha -cardiac actin, both activated in part by Nkx2-5 DNA binding elements, also increased with RVH. These data suggest that a cardiac homeobox gene may play a role in the induction of adult cardiac hypertrophy.

cardiac hypertrophy; pulmonary artery banding


This article has been cited by other articles:


Home page
 Eur. J. Cardiothorac. Surg.Home page
B. Davies, Y. d'Udekem, O. C. Ukoumunne, E. M. Algar, D. F. Newgreen, and C. P. Brizard
Differences in extra-cellular matrix and myocyte homeostasis between the neonatal right ventricle in hypoplastic left heart syndrome and truncus arteriosus
Eur. J. Cardiothorac. Surg., October 1, 2008; 34(4): 738 - 744.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
J. A. Epstein
Developmental Cardiology Comes of Age
Circ. Res., November 10, 2000; 87(10): 833 - 834.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online