| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Department of Anatomy and Cell Biology and The Cardiovascular Center, University of Iowa, Iowa City, Iowa 52242; and Department of Pediatrics, University of Rochester, Rochester, New York 14642
We tested the hypothesis that early vascularization of the embryonic heart is enhanced after bolus injections of vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) into the vitelline vein before the onset of myocardial vasculogenesis (3.5 days, stage 21). Electron and light microscopy were utilized to obtain morphometric data. At stages 29 and 31, myocardial vessel volume or numerical density were higher in embryos injected with 50 ng bFGF than in the saline-injected controls. A VEGF injection increased vascular volume density at stage 29 and both volume and numerical density at stage 31. bFGF, but not VEGF, was associated with an enhancement of the sinusoidal system (spongy layer of the ventricle) at stage 29. This effect disappeared by stage 31. In conclusion, 1) enhancement of bFGF or VEGF before myocardial vascularization increases vascular growth, but the initial effect of bFGF is greater; 2) the effects of these growth factors on vascular volume and numerical density are temporally dependent; and 3) bFGF, in addition to its effects on the coronary vasculature, influences ventricular modeling by apparently acting on myocytes as well as endothelial cells.
vasculogenesis; angiogenesis; heart development
This article has been cited by other articles:
|
|
 |
|
  C. E. Mascio, A. K. Olison, J. C. Ralphe, R. J. Tomanek, T. D. Scholz, and J. L. Segar Myocardial vascular and metabolic adaptations in chronically anemic fetal sheep Am J Physiol Regulatory Integrative Comp Physiol, December 1, 2005; 289(6): R1736 - R1745. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. L. Brutsaert Cardiac Endothelial-Myocardial Signaling: Its Role in Cardiac Growth, Contractile Performance, and Rhythmicity Physiol Rev, January 1, 2003; 83(1): 59 - 115. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. Zhao, X. Lu, and Q. Feng Deficiency in endothelial nitric oxide synthase impairs myocardial angiogenesis Am J Physiol Heart Circ Physiol, December 1, 2002; 283(6): H2371 - H2378. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Sheikh, D. P. Sontag, R. R. Fandrich, E. Kardami, and P. A. Cattini Overexpression of FGF-2 increases cardiac myocyte viability after injury in isolated mouse hearts Am J Physiol Heart Circ Physiol, March 1, 2001; 280(3): H1039 - H1050. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. J. Tomanek, A. Sandra, W. Zheng, T. Brock, R. J. Bjercke, and J. S. Holifield Vascular Endothelial Growth Factor and Basic Fibroblast Growth Factor Differentially Modulate Early Postnatal Coronary Angiogenesis Circ. Res., June 8, 2001; 88(11): 1135 - 1141. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
