AJP - Heart Calcium Transients and Cell-Sarcomere
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Heart Circ Physiol 274: H1635-H1642, 1998;
0363-6135/98 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by O'Hagan, K. P.
Right arrow Articles by Casey, S. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by O'Hagan, K. P.
Right arrow Articles by Casey, S. M.
Vol. 274, Issue 5, H1635-H1642, May 1998

Arterial baroreflex during pregnancy and renal sympathetic nerve activity during parturition in rabbits

Kathleen P. O'Hagan and Susan M. Casey

Department of Physiology, Chicago College of Osteopathic Medicine, Midwestern University, Downers Grove, Illinois 60515

The arterial baroreflex control of renal sympathetic nerve activity (RSNA) was evaluated in nine term pregnant (P) and 12 nonpregnant (NP) conscious New Zealand White rabbits. In an additional four P rabbits, the RSNA response to spontaneous parturition was measured. The blood pressure (BP)-RSNA relationship was generated by sequential inflations of aortic and vena caval perivascular occluders. Rest BP (P: 61 ± 2 vs. NP: 73 ± 2 mmHg) and the centering point of the baroreflex (P: 57 ± 2 vs. NP: 70 ± 2 mmHg) were lower (P < 0.05) in term pregnancy. Baroreflex range (P: 246 ± 14% vs. NP 263 ± 24% of rest RSNA) was not affected by pregnancy. However, maximal reflex gain was moderately depressed (-44%) in P rabbits (P: -15 ± 1 vs. NP: -27 ± 4% of rest RSNA/mmHg; P < 0.05) due to a significant reduction in the slope coefficient. Delivery of a fetus was associated with strong renal sympathoexcitation. Peak RSNA averaged 80 ± 37% of smoke-elicited RSNA or 1,221 ± 288% of rest RSNA (mean ± SD). These results suggest that, in contrast to rat pregnancy, depressed arterial baroreflex control of RSNA in rabbit pregnancy is due primarily to a reduction in maximal gain rather than a reduction in the maximal sympathetic response to hypotension.

blood pressure; sympathetic nervous system; labor


This article has been cited by other articles:


Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
L. Kvochina, E. M. Hasser, and C. M. Heesch
Pregnancy increases baroreflex-independent GABAergic inhibition of the RVLM in rats
Am J Physiol Regulatory Integrative Comp Physiol, December 1, 2007; 293(6): R2295 - R2305.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
A. E. Nesbitt, R. J. Murphy, and K. P. O'Hagan
Effect of gestational stage on uterine artery blood flow during exercise in rabbits
J Appl Physiol, December 1, 2005; 99(6): 2159 - 2165.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
K. P. O'Hagan and J. A. Alberts
Uterine artery blood flow and renal sympathetic nerve activity during exercise in rabbit pregnancy
Am J Physiol Regulatory Integrative Comp Physiol, November 1, 2003; 285(5): R1135 - R1144.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
V. L. Brooks, K. A. Clow, and K. P. O'Hagan
Pregnancy and acute baroreflex resetting in conscious rabbits
Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2002; 283(2): R429 - R440.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
K. P. O'Hagan, K. A. Skogg, and J. B. Stevenson
AT1 receptor block does not affect arterial baroreflex during pregnancy in rabbits
Am J Physiol Heart Circ Physiol, May 1, 2001; 280(5): H1996 - H2005.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online