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Am J Physiol Heart Circ Physiol 274: H1761-H1766, 1998;
0363-6135/98 $5.00
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Vol. 274, Issue 5, H1761-H1766, May 1998

R-R variability detects increases in vagal modulation with phenylephrine infusion

Daniel M. Bloomfield, Steven Zweibel, J. Thomas Bigger Jr., and Richard C. Steinman

Division of Cardiology, Department of Medicine, Columbia University, New York, New York 10032

High-frequency power, measured from power spectral analysis of R-R variability, reflects vagal modulation of the sinus node. Unexpectedly, a recent study reported a decrease in high-frequency power during the infusion of phenylephrine despite a prolongation of R-R intervals, indicating an increase in vagal activity. To better define the limitations of high-frequency power to quantify vagal modulation, we measured high-frequency power during the infusion of phenylephrine (0.4, 0.8, and 1.2 µg · kg-1 · min-1) into 10 normal subjects. We found increasing doses of phenylephrine produced progressive increases in systolic blood pressure from 118 ± 4 to 129 ± 5 mmHg (P < 0.005), R-R intervals from 881 ± 44 to 1,274 ± 69 ms (P < 0.0001), and the logarithm of high-frequency power from 5.83 ± 0.22 to 7.73 ± 0.24 ln(ms2) (P < 0.0001). The conclusion was high-frequency power increases with increasing doses of phenylephrine. These data strongly support the ability of high-frequency power to detect an increase in vagal modulation during baroreceptor activation from an increase in systolic blood pressure with the infusion of phenylephrine.

heart rate variability; power spectral analysis; parasympathetic nervous system; baroreceptor activation; baroreflex


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