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Am J Physiol Heart Circ Physiol 274: H1828-H1835, 1998;
0363-6135/98 $5.00
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Vol. 274, Issue 5, H1828-H1835, May 1998

SPECIAL COMMUNICATION
End-systolic stress-velocity and pressure-dimension relationships by transthoracic echocardiography in mice

Richard V. Williams1, John N. Lorenz2, Sandra A. Witt1, David T. Hellard2, Philip R. Khoury1, and Thomas R. Kimball1

1 Noninvasive Cardiac Imaging and Hemodynamic Research Laboratory, Division of Cardiology and the 2 Mouse Physiology Core Facility, Department of Molecular and Cellular Physiology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229

The purposes of this study were to assess load-independent, end-systolic relationships in mice and compare these relationships to ejection phase indexes in assessing contractility. In 13 mice, ejection phase indexes (shortening fraction and velocity of fiber shortening) and end-systolic relationships [pressure-dimension relationship (ESPDR) and stress-velocity relationship (ESSVR)] were determined using M-mode echocardiography and simultaneous left ventricular pressure. Load was altered with phenylephrine and nitroprusside. Contractility was increased with dobutamine and decreased by induction of hypothyroidism. Ejection phase indexes increased with dobutamine infusion but were not significantly decreased with hypothyroidism. However, end-systolic relationships changed significantly with both dobutamine (y-intercepts: ESPDR from 22 to 48 mmHg, ESSVR from 3.7 to 6.6 circ/s, P < 0.05) and hypothyroidism (y-intercepts: ESPDR from 22 to 11 mmHg, ESSVR from 3.7 to 3.2 circ/s, P < 0.05). We conclude that end-systolic indexes can be accurately measured in the intact mouse by echocardiography with simultaneous left ventricular pressure recording and appear to be more sensitive to inotropic state than ejection phase indexes.

myocardial contractility; murine physiology


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