| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
1 Department of Physiology, Health Science Center at Syracuse, State University of New York, Syracuse, New York 13210; and 2 Department of Cell Biology and Anatomy, Medical University of South Carolina, Charleston, South Carolina 29425
This study evaluated whether daily exercise would enhance the peripheral collateral vessel development found in response to exogenous basic fibroblast growth factor (bFGF) infusion. After bilateral femoral occlusion, male Sprague-Dawley rats (~325 g) received intra-arterial infusions of either bFGF (1 µg/day; n = 15) or carrier solution (n = 13) via osmotic pumps for 2 wk. Subgroups of each treatment were kept sedentary (cage activity) or trained by walking at 20 m/min at 15% grade, two times a day, 5 days/wk for 4 wk. Training markedly increased citrate synthase activity in the active muscle (P < 0.001). Muscle function and blood flows (85Sr microsphere) were evaluated using an isolated hindquarter perfused at 100 mmHg via the abdominal aorta. The significant increase in blood flow to the entire hindlimb in the sedentary animals, caused by bFGF infusion (P < 0.05), was further increased (P < 0.01) in the bFGF-trained group. The quantitatively largest increases in blood flows were observed in the collateral-dependent tissues of the distal hindlimb. Blood flows to the entire calf muscle group increased ~140% in carrier-trained (P < 0.001), ~180% in bFGF sedentary (P < 0.001), and ~240% in the bFGF-trained (P < 0.001) groups compared with the carrier sedentary group. The increases in collateral blood flow were functionally important, as improvements in calf muscle performance correlated with measured blood flows. Our results demonstrate that exogenous bFGF administration in combination with a moderate-intensity exercise program greatly increases collateral-dependent blood flow and improves muscle performance. That physical activity enriched the bFGF response is consistent with the hypothesis that hemodynamic factors are important contributors to collateral vessel enlargement.
vascular remodeling; angiogenesis; intermittent claudication; muscle contraction; muscle fiber type; microspheres
This article has been cited by other articles:
|
|
 |
|
  P. G. Lloyd, B. M. Prior, H. Li, H. T. Yang, and R. L. Terjung VEGF receptor antagonism blocks arteriogenesis, but only partially inhibits angiogenesis, in skeletal muscle of exercise-trained rats Am J Physiol Heart Circ Physiol, February 1, 2005; 288(2): H759 - H768. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. M. Prior, P. G. Lloyd, J. Ren, H. Li, H. T. Yang, M. H. Laughlin, and R. L. Terjung Time course of changes in collateral blood flow and isolated vessel size and gene expression after femoral artery occlusion in rats Am J Physiol Heart Circ Physiol, December 1, 2004; 287(6): H2434 - H2447. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. M. Prior, H. T. Yang, and R. L. Terjung What makes vessels grow with exercise training? J Appl Physiol, September 1, 2004; 97(3): 1119 - 1128. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Ueda, M. Koga, M. Ikeda, S. Kudo, and K. Tanishita Effect of shear stress on microvessel network formation of endothelial cells with in vitro three-dimensional model Am J Physiol Heart Circ Physiol, September 1, 2004; 287(3): H994 - H1002. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Tang, E. C. Breen, H.-P. Gerber, N. M. A. Ferrara, and P. D. Wagner Capillary regression in vascular endothelial growth factor-deficient skeletal muscle Physiol Genomics, June 17, 2004; 18(1): 63 - 69. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. C Hershey, H. A Corcoran, E. P Baskin, D. B Gilberto, X. Mao, K. A Thomas, and J. J Cook Enhanced hindlimb collateralization induced by acidic fibroblast growth factor is dependent upon femoral artery extraction Cardiovasc Res, October 1, 2003; 59(4): 997 - 1005. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Srivastava, R. L. Terjung, and H. T. Yang Basic fibroblast growth factor increases collateral blood flow in spontaneously hypertensive rats Am J Physiol Heart Circ Physiol, August 7, 2003; 285(3): H1190 - H1197. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. G. Lloyd, B. M. Prior, H. T. Yang, and R. L. Terjung Angiogenic growth factor expression in rat skeletal muscle in response to exercise training Am J Physiol Heart Circ Physiol, May 1, 2003; 284(5): H1668 - H1678. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Gloe, H. Y. Sohn, G. A. Meininger, and U. Pohl Shear Stress-induced Release of Basic Fibroblast Growth Factor from Endothelial Cells Is Mediated by Matrix Interaction via Integrin alpha Vbeta 3 J. Biol. Chem., June 21, 2002; 277(26): 23453 - 23458. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. T. Yang, J. Ren, M. H. Laughlin, and R. L. Terjung Prior exercise training produces NO-dependent increases in collateral blood flow after acute arterial occlusion Am J Physiol Heart Circ Physiol, January 1, 2002; 282(1): H301 - H310. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. G. Lloyd, H. T. Yang, and R. L. Terjung Arteriogenesis and angiogenesis in rat ischemic hindlimb: role of nitric oxide Am J Physiol Heart Circ Physiol, December 1, 2001; 281(6): H2528 - H2538. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. T. Yang, Z. Yan, J. A. Abraham, and R. L. Terjung VEGF121- and bFGF-induced increase in collateral blood flow requires normal nitric oxide production Am J Physiol Heart Circ Physiol, March 1, 2001; 280(3): H1097 - H1104. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. T. Yang, M. H. Laughlin, and R. L. Terjung Prior exercise training increases collateral-dependent blood flow in rats after acute femoral artery occlusion Am J Physiol Heart Circ Physiol, October 1, 2000; 279(4): H1890 - H1897. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. T. Yang, Y. Feng, L. A. Allen, A. Protter, and R. L. Terjung Efficacy and specificity of bFGF increased collateral flow in experimental peripheral arterial insufficiency Am J Physiol Heart Circ Physiol, June 1, 2000; 278(6): H1966 - H1973. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. T. Yang and Y. Feng bFGF increases collateral blood flow in aged rats with femoral artery ligation Am J Physiol Heart Circ Physiol, January 1, 2000; 278(1): H85 - H93. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
