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Am J Physiol Heart Circ Physiol 274: H2053-H2061, 1998;
0363-6135/98 $5.00
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Vol. 274, Issue 6, H2053-H2061, June 1998

Exercise training enhances basic fibroblast growth factor-induced collateral blood flow

H. T. Yang1, Robert W. Ogilvie2, and Ronald L. Terjung1

1 Department of Physiology, Health Science Center at Syracuse, State University of New York, Syracuse, New York 13210; and 2 Department of Cell Biology and Anatomy, Medical University of South Carolina, Charleston, South Carolina 29425

This study evaluated whether daily exercise would enhance the peripheral collateral vessel development found in response to exogenous basic fibroblast growth factor (bFGF) infusion. After bilateral femoral occlusion, male Sprague-Dawley rats (~325 g) received intra-arterial infusions of either bFGF (1 µg/day; n = 15) or carrier solution (n = 13) via osmotic pumps for 2 wk. Subgroups of each treatment were kept sedentary (cage activity) or trained by walking at 20 m/min at 15% grade, two times a day, 5 days/wk for 4 wk. Training markedly increased citrate synthase activity in the active muscle (P < 0.001). Muscle function and blood flows (85Sr microsphere) were evaluated using an isolated hindquarter perfused at 100 mmHg via the abdominal aorta. The significant increase in blood flow to the entire hindlimb in the sedentary animals, caused by bFGF infusion (P < 0.05), was further increased (P < 0.01) in the bFGF-trained group. The quantitatively largest increases in blood flows were observed in the collateral-dependent tissues of the distal hindlimb. Blood flows to the entire calf muscle group increased ~140% in carrier-trained (P < 0.001), ~180% in bFGF sedentary (P < 0.001), and ~240% in the bFGF-trained (P < 0.001) groups compared with the carrier sedentary group. The increases in collateral blood flow were functionally important, as improvements in calf muscle performance correlated with measured blood flows. Our results demonstrate that exogenous bFGF administration in combination with a moderate-intensity exercise program greatly increases collateral-dependent blood flow and improves muscle performance. That physical activity enriched the bFGF response is consistent with the hypothesis that hemodynamic factors are important contributors to collateral vessel enlargement.

vascular remodeling; angiogenesis; intermittent claudication; muscle contraction; muscle fiber type; microspheres


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