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Am J Physiol Heart Circ Physiol 274: H2094-H2099, 1998;
0363-6135/98 $5.00
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Vol. 274, Issue 6, H2094-H2099, June 1998

Estrogen restores role of basal nitric oxide in control of vascular tone in rats with chronic heart failure

Ali Akbar Nekooeian and Catherine C. Y. Pang

Department of Pharmacology and Therapeutics, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z3

This study examined the cardiovascular effects of 17beta -estradiol in ovariectomized rats with heart failure. Two groups (50-60 days old) were implanted with 60-day-release pellets containing 17beta -estradiol (25 µg/day) or vehicle at 7 days before ligation of the left coronary artery. Another group was sham operated and given vehicle pellets. After 7 wk, they were studied under pentobarbital anesthesia. Relative to sham-operated rats, ligated rats had reduced mean arterial pressure (MAP, -24 ± 6 mmHg), cardiac output (-27 ± 4 ml/min), left ventricular (LV) end-systolic pressure (-29 ± 8 mmHg), depressor responses to ACh (-6 ± 4 mmHg at 7.2 µg/kg) and sodium nitroprusside (SNP, -22 ± 6 mmHg at 9 µg/kg), and pressor responses to NG-nitro-L-arginine methyl ester (L-NAME, -14 ± 6 mmHg at 8 mg/kg) and increased LV end-diastolic pressure (LVEDP, 10.3 ± 0.8 mmHg) but no change in total peripheral resistance (TPR). Treatment of ligated rats with 17beta -estradiol reduced TPR (-0.19 ± 0.06 mmHg · min · ml-1), LVEDP (-3.6 ± 1 mmHg), and responses to ACh (-16 ± 4 mmHg) and augmented responses to L-NAME (14 ± 3 mmHg) but did not alter other variables. Therefore, 17beta -estradiol reduces preload and afterload and restores the vasodilator role of basal nitric oxide in ovariectomized rats with chronic heart failure.

17beta -estradiol; NG-nitro-L-arginine methyl ester; cardiac output; acetylcholine; left ventricular end-diastolic pressure


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