AJP - Heart Email Content Delivery
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Heart Circ Physiol 274: H2163-H2176, 1998;
0363-6135/98 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Vaughn, M. W.
Right arrow Articles by Liao, J. C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Vaughn, M. W.
Right arrow Articles by Liao, J. C.
Vol. 274, Issue 6, H2163-H2176, June 1998

MODELING IN PHYSIOLOGY
Estimation of nitric oxide production and reaction
rates in tissue by use of a mathematical model

Mark W. Vaughn1, Lih Kuo2, and James C. Liao3

1 Department of Chemical Engineering, Texas A&M University, 2 Department of Medical Physiology, Texas A&M University Health Science Center, College Station, Texas 77843; and 3 Department of Chemical Engineering, University of California, Los Angeles, California 90095

Nitric oxide (NO) produced by the vascular endothelium is an important biologic messenger that regulates vessel tone and permeability and inhibits platelet adhesion and aggregation. NO exerts its control of vessel tone by interacting with guanylyl cyclase in the vascular smooth muscle to initiate a series of reactions that lead to vessel dilation. Previous efforts to investigate this interaction by mathematical modeling of NO diffusion and reaction have been hampered by the lack of information on the production and degradation rate of NO. We use a mathematical model and previously published experimental data to estimate the rate of NO production, 6.8 × 10-14 µmol · µm-2 · s-1; the NO diffusion coefficient, 3,300 µm2 s-1; and the NO consumption rate coefficient in the vascular smooth muscle, 0.01 s-1 (1st-order rate expression) or 0.05 µM-1 · s-1 (2nd-order rate expression). The modeling approach is discussed in detail. It provides a general framework for modeling the NO produced from the endothelium and for estimating relevant physical parameters.

mass transfer; kinetics; parameter estimation; diffusion


This article has been cited by other articles:


Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
R. M. Dongaonkar, R. H. Stewart, G. A. Laine, M. J. Davis, D. C. Zawieja, and C. M. Quick
Venomotion modulates lymphatic pumping in the bat wing
Am J Physiol Heart Circ Physiol, June 1, 2009; 296(6): H2015 - H2021.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
W. Zhang and A. Edwards
A model of nitric oxide tubulovascular cross talk in a renal outer medullary cross section
Am J Physiol Renal Physiol, February 1, 2007; 292(2): F711 - F722.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
M. Kavdia and A. S. Popel
Venular endothelium-derived NO can affect paired arteriole: a computational model
Am J Physiol Heart Circ Physiol, February 1, 2006; 290(2): H716 - H723.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
J. Yang, J. W. Clark, R. M. Bryan, and C. S. Robertson
Mathematical modeling of the nitric oxide/cGMP pathway in the vascular smooth muscle cell
Am J Physiol Heart Circ Physiol, August 1, 2005; 289(2): H886 - H897.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
D. R. Hyduke and J. C. Liao
Analysis of nitric oxide donor effectiveness in resistance vessels
Am J Physiol Heart Circ Physiol, May 1, 2005; 288(5): H2390 - H2399.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
A. G. Tsai, C. Acero, P. R. Nance, P. Cabrales, J. A. Frangos, D. G. Buerk, and M. Intaglietta
Elevated plasma viscosity in extreme hemodilution increases perivascular nitric oxide concentration and microvascular perfusion
Am J Physiol Heart Circ Physiol, April 1, 2005; 288(4): H1730 - H1739.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
W. Zhang, T. Pibulsonggram, and A. Edwards
Determinants of basal nitric oxide concentration in the renal medullary microcirculation
Am J Physiol Renal Physiol, December 1, 2004; 287(6): F1189 - F1203.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
M. Kavdia and A. S. Popel
Contribution of nNOS- and eNOS-derived NO to microvascular smooth muscle NO exposure
J Appl Physiol, July 1, 2004; 97(1): 293 - 301.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
N. M. Tsoukias, M. Kavdia, and A. S. Popel
A theoretical model of nitric oxide transport in arterioles: frequency- vs. amplitude-dependent control of cGMP formation
Am J Physiol Heart Circ Physiol, March 1, 2004; 286(3): H1043 - H1056.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
K. M. Smith, L. C. Moore, and H. E. Layton
Advective transport of nitric oxide in a mathematical model of the afferent arteriole
Am J Physiol Renal Physiol, May 1, 2003; 284(5): F1080 - F1096.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
P. Condorelli and S. C. George
Free nitric oxide diffusion in the bronchial microcirculation
Am J Physiol Heart Circ Physiol, December 1, 2002; 283(6): H2660 - H2670.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
M. Kavdia, N. M. Tsoukias, and A. S. Popel
Model of nitric oxide diffusion in an arteriole: impact of hemoglobin-based blood substitutes
Am J Physiol Heart Circ Physiol, June 1, 2002; 282(6): H2245 - H2253.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
N. M. Tsoukias and A. S. Popel
Erythrocyte consumption of nitric oxide in presence and absence of plasma-based hemoglobin
Am J Physiol Heart Circ Physiol, June 1, 2002; 282(6): H2265 - H2277.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
A. Vadapalli, R. N. Pittman, and A. S. Popel
Estimating oxygen transport resistance of the microvascular wall
Am J Physiol Heart Circ Physiol, August 1, 2000; 279(2): H657 - H671.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
M. Kavdia, N. M. Tsoukias, and A. S. Popel
Model of nitric oxide diffusion in an arteriole: impact of hemoglobin-based blood substitutes
Am J Physiol Heart Circ Physiol, June 1, 2002; 282(6): H2245 - H2253.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
N. M. Tsoukias and A. S. Popel
Erythrocyte consumption of nitric oxide in presence and absence of plasma-based hemoglobin
Am J Physiol Heart Circ Physiol, June 1, 2002; 282(6): H2265 - H2277.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online