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Am J Physiol Heart Circ Physiol 275: H1-H7, 1998;
0363-6135/98 $5.00
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Vol. 275, Issue 1, H1-H7, July 1998

INVITED REVIEW
"Physiological genomics": mutant screens in zebrafish

Kerri S. Warren and Mark C. Fishman

Cardiovascular Research Center, Massachusetts General Hospital, Charlestown 02129; and Harvard Medical School, Boston, Massachusetts 02115

Large-scale mutagenesis screens have proved essential in the search for genes that are important to development in the fly, worm, and yeast. Here we present the power of large-scale screening in a vertebrate, the zebrafish Danio rerio, and propose the use of this genetic system to address fundamental questions of vertebrate developmental physiology. As an example, we focus on zebrafish mutations that reveal single genes essential for normal development of the cardiovascular system. These single gene mutations disrupt specific aspects of rate, rhythm, conduction, or contractility of the developing heart.

mutagenesis; embryonic physiology; embryonic cardiovasculature; vertebrate genetic screen


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