AJP - Heart AJP: Endocrinology and Metabolism
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Heart Circ Physiol 275: H15-H22, 1998;
0363-6135/98 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Kähönen, M.
Right arrow Articles by Pörsti, I.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kähönen, M.
Right arrow Articles by Pörsti, I.
Vol. 275, Issue 1, H15-H22, July 1998

Influence of gender on control of arterial tone in experimental hypertension

Mika Kähönen1,2, Jari-Petteri Tolvanen1,3, Kirsimarja Sallinen1, Xiumin Wu1, and Ilkka Pörsti1,4

1 Department of Pharmacological Sciences, Medical School, University of Tampere, FIN-33101 Tampere; and Departments of 2 Clinical Physiology, 3 Clinical Chemistry, and 4 Internal Medicine, Tampere University Hospital, FIN-33521 Tampere, Finland

Endothelial dysfunction has been found to be less severe in female than in male spontaneously hypertensive rats (SHR), which could contribute to the gender differences observed in the extent and rate of progression of hypertension in SHR. However, the influence of gender on the roles of different endothelium-derived mediators in the arterial responses in hypertension have not been evaluated in detail. Therefore, contractile and relaxation responses of mesenteric arterial rings in vitro were studied in female and male SHR, with normotensive female and male Wistar-Kyoto rats (WKY) serving as controls. In norepinephrine (NE)-precontracted arterial rings, endothelium-dependent relaxations to ACh as well as endothelium-independent dilations to sodium nitroprusside were more pronounced in female than in male SHR, whereas relaxations to the beta -adrenoceptor agonist isoproterenol remained equally impaired in female and male SHR. The cyclooxygenase inhibitor diclofenac, which reduces the synthesis of dilating and constricting prostanoids, markedly enhanced the relaxations to ACh in male SHR but not in the other groups. The nitric oxide (NO) synthase inhibitor NG-nitro-L-arginine methyl ester attenuated the relaxations to ACh more effectively in female SHR and WKY than in the male groups. However, when endothelium-dependent hyperpolarization was prevented by precontracting the preparations with KCl, no significant differences were found in relaxations to ACh among the study groups. In conclusion, release of cyclooxygenase-derived constricting factors appeared to be more pronounced in male than in female SHR. In addition, the relative role of NO in endothelium-dependent arterial relaxation seemed to be higher in female than in male SHR, and relaxation induced by an NO donor also was more pronounced in female than in male SHR.

arterial smooth muscle; endothelium; spontaneously hypertensive rat; Wistar-Kyoto rat


This article has been cited by other articles:


Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
J. C. Sullivan, J. L. Pardieck, D. Doran, Y. Zhang, J.-X. She, and J. S. Pollock
Greater fractalkine expression in mesenteric arteries of female spontaneously hypertensive rats compared with males
Am J Physiol Heart Circ Physiol, April 1, 2009; 296(4): H1080 - H1088.
[Abstract] [Full Text] [PDF]

Home page
 Ther Adv Cardiovasc DisHome page
P. D. Patel and R. R. Arora
Review: Endothelial dysfunction: A potential tool in gender related cardiovascular disease
Therapeutic Advances in Cardiovascular Disease, April 1, 2008; 2(2): 89 - 100.
[Abstract] [PDF]

Home page
 J. Appl. Physiol.Home page
B. A. Parker, S. L. Smithmyer, J. A. Pelberg, A. D. Mishkin, M. D. Herr, and D. N. Proctor
Sex differences in leg vasodilation during graded knee extensor exercise in young adults
J Appl Physiol, November 1, 2007; 103(5): 1583 - 1591.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
J. Palacios, E. T. Marusic, N. C. Lopez, M. Gonzalez, and L. Michea
Estradiol-induced expression of Na+-K+-ATPase catalytic isoforms in rat arteries: gender differences in activity mediated by nitric oxide donors
Am J Physiol Heart Circ Physiol, May 1, 2004; 286(5): H1793 - H1800.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
J. M. Orshal and R. A. Khalil
Gender, sex hormones, and vascular tone
Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2004; 286(2): R233 - R249.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
A. P. McKee, D. A. Van Riper, C. A. Davison, and H. A. Singer
Gender-dependent modulation of alpha 1-adrenergic responses in rat mesenteric arteries
Am J Physiol Heart Circ Physiol, May 1, 2003; 284(5): H1737 - H1743.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
H. L. Xu, R. A. Santizo, H. M. Koenig, and D. A. Pelligrino
Chronic estrogen depletion alters adenosine diphosphate-induced pial arteriolar dilation in female rats
Am J Physiol Heart Circ Physiol, November 1, 2001; 281(5): H2105 - H2112.
[Abstract] [Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
K. G. Lamping and F. M. Faraci
Role of Sex Differences and Effects of Endothelial NO Synthase Deficiency in Responses of Carotid Arteries to Serotonin
Arterioscler Thromb Vasc Biol, April 1, 2001; 21(4): 523 - 528.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online