AJP - Heart Calcium Transients and Cell-Sarcomere
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Heart Circ Physiol 275: H250-H258, 1998;
0363-6135/98 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Yue, P.
Right arrow Articles by Long, C. S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Yue, P.
Right arrow Articles by Long, C. S.
Vol. 275, Issue 1, H250-H258, July 1998

Cytokine expression increases in nonmyocytes from rats with postinfarction heart failure

Ping Yue2, Barry M. Massie1,2,3, Paul C. Simpson1,2,3, and Carlin S. Long1,2,3

1 Department of Medicine and 2 Cardiovascular Research Institute, University of California, San Francisco 94143; and 3 Cardiology Section, Department of Veterans Affairs Medical Center, San Francisco, California 94121

Growing evidence suggests that cardiac nonmyocyte cells may play an important regulatory role in the response to myocardial overload and injury via altered expression of paracrine products, such as cytokines and growth factors, but information concerning the cell-specific changes in the expression of these substances in heart-failure models is limited. Therefore, cardiac nonmyocytes were isolated from rats 1 day and 1 and 6 wk after left coronary artery ligation with resulting hemodynamic evidence of heart failure and in sham-operated control animals. mRNAs for tumor necrosis factor-alpha (TNF-alpha ), interleukin (IL)-1beta , IL-6, transforming growth factors (TGF)-beta 1 and TGF-beta 3, and type I and type III collagen were measured by Northern analyses. The temporal and quantitative relationships between the expression of these cytokines and collagen and myocyte hypertrophy were determined. mRNA expression of IL-1beta was increased by 1.3-fold at 1 day and 1 wk, and expression of TNF-alpha , IL-1beta , IL-6, TGF-beta 1, and TGF-beta 3 were increased by 1.4- to 2.1-fold at the 1-wk time point before returning toward baseline at 6 wk. There were significant correlations between the expression of these cytokines and the expression of types I and III collagen, which also peaked at 1 wk. Myocyte hypertrophy was seen first at 6 wk. These observations are consistent with a hypothesis that nonmyocyte cells play a regulatory role in the extracellular matrix changes during postinfarction remodeling and highlight the importance of examining cell-specific changes in gene expression and elucidating the role of cell-to-cell interactions within the myocardium.

myocardial infarction; cardiac myocytes; fibroblasts; gene expression


This article has been cited by other articles:


Home page
 Am. J. Physiol. Cell Physiol.Home page
D. J. H. Mountain, M. Singh, B. Menon, and K. Singh
Interleukin-1beta increases expression and activity of matrix metalloproteinase-2 in cardiac microvascular endothelial cells: role of PKC{alpha}/beta1 and MAPKs
Am J Physiol Cell Physiol, February 1, 2007; 292(2): C867 - C875.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
P. J. Lafontant, A. R. Burns, E. Donnachie, S. B. Haudek, C. W. Smith, and M. L. Entman
Oncostatin M differentially regulates CXC chemokines in mouse cardiac fibroblasts
Am J Physiol Cell Physiol, July 1, 2006; 291(1): C18 - C26.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
J. Francis, Y. Chu, A. K. Johnson, R. M. Weiss, and R. B. Felder
Acute myocardial infarction induces hypothalamic cytokine synthesis
Am J Physiol Heart Circ Physiol, June 1, 2004; 286(6): H2264 - H2271.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
P. O. Iversen, P. R. Woldbaek, T. Tonnessen, and G. Christensen
Decreased hematopoiesis in bone marrow of mice with congestive heart failure
Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2002; 282(1): R166 - R172.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
P. O. Iversen, G. Nicolaysen, and M. Sioud
DNA enzyme targeting TNF-alpha mRNA improves hemodynamic performance in rats with postinfarction heart failure
Am J Physiol Heart Circ Physiol, November 1, 2001; 281(5): H2211 - H2217.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
J. P. Loennechen, A. Stoylen, V. Beisvag, U. Wisloff, and O. Ellingsen
Regional expression of endothelin-1, ANP, IGF-1, and LV wall stress in the infarcted rat heart
Am J Physiol Heart Circ Physiol, June 1, 2001; 280(6): H2902 - H2910.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
F. Sam, D. B. Sawyer, D. L.-F. Chang, F. R. Eberli, S. Ngoy, M. Jain, J. Amin, C. S. Apstein, and W. S. Colucci
Progressive left ventricular remodeling and apoptosis late after myocardial infarction in mouse heart
Am J Physiol Heart Circ Physiol, July 1, 2000; 279(1): H422 - H428.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
Q. He and M. C. LaPointe
Interleukin-1{beta} Regulates the Human Brain Natriuretic Peptide Promoter via Ca2+-Dependent Protein Kinase Pathways
Hypertension, January 1, 2000; 35(1): 292 - 296.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
D. Gurantz, R. T. Cowling, F. J. Villarreal, and B. H. Greenberg
Tumor Necrosis Factor-{alpha} Upregulates Angiotensin II Type 1 Receptors on Cardiac Fibroblasts
Circ. Res., August 6, 1999; 85(3): 272 - 279.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
N. A. Trueblood, Z. Xie, C. Communal, F. Sam, S. Ngoy, L. Liaw, A. W. Jenkins, J. Wang, D. B. Sawyer, O. H. L. Bing, et al.
Exaggerated Left Ventricular Dilation and Reduced Collagen Deposition After Myocardial Infarction in Mice Lacking Osteopontin
Circ. Res., May 25, 2001; 88(10): 1080 - 1087.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
F. Sam, D. B. Sawyer, Z. Xie, D. L.F. Chang, S. Ngoy, D. A. Brenner, D. A. Siwik, K. Singh, C. S. Apstein, and W. S. Colucci
Mice Lacking Inducible Nitric Oxide Synthase Have Improved Left Ventricular Contractile Function and Reduced Apoptotic Cell Death Late After Myocardial Infarction
Circ. Res., August 17, 2001; 89(4): 351 - 356.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online