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Am J Physiol Heart Circ Physiol 275: H400-H408, 1998;
0363-6135/98 $5.00
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Vol. 275, Issue 2, H400-H408, August 1998

Dynamic sympathetic regulation of left ventricular contractility studied in the isolated canine heart

Hiroshi Miyano1, Yasunori Nakayama1, Toshiaki Shishido1, Masashi Inagaki1, Toru Kawada1, Takayuki Sato1, Hiroshi Miyashita1, Masaru Sugimachi1, Joe Alexander Jr.2, and Kenji Sunagawa1

1 Department of Cardiovascular Dynamics, National Cardiovascular Center Research Institute, Osaka 565, Japan; and 2 Department of Biomedical Engineering, Vanderbilt University, Nashville, Tennessee 37235

We investigated the dynamic sympathetic regulation of left ventricular end-systolic elastance (Ees) using an isolated canine ventricular preparation with functioning sympathetic nerves intact. We estimated the transfer function from both stellate ganglion stimulation to Ees and ganglion stimulation to heart rate (HR) for both left and right ganglia by means of the white noise approach and transformed those transfer functions into corresponding step responses. The HR response was much larger with right sympathetic stimulation than with left sympathetic stimulation (4.3 ± 1.4 vs. 0.7 ± 0.6 beats · min-1 · Hz-1, P < 0.01). In contrast, the Ees responses without pacing were not significantly different between left and right sympathetic stimulation (0.72 ± 0.34 vs. 0.76 ± 0.42 mmHg · ml-1 · Hz-1). Fixed-rate pacing significantly decreased the Ees response to right sympathetic stimulation (0.53 ± 0.43 mmHg · ml-1 · Hz-1, P < 0.01), but not to left sympathetic stimulation (0.67 ± 0.32 mmHg · ml-1 · Hz-1, not significant). Although the mechanism by which the sympathetic nervous system regulates cardiac contractility is different depending on whether the left or right sympathetic nerves are activated, this difference does not affect the apparent response of Ees to dynamic sympathetic stimulation.

left ventricular end-systolic elastance; transfer function; sympathetic nervous system; inotropic action; force-frequency mechanism


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