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-receptor regulation
Department of Physiology and Pharmacology, Auburn University, Auburn, Alabama 36849
The objectives of this study were
1) to determine whether ANG
II-induced myocardial damage (ANG Dam) is mediated via the
1-adrenergic receptor,
2) to elucidate whether adrenal
medulla or cardiac sympathetic neuron catecholamines are responsible
for ANG Dam, and 3) to determine whether the lack of damage after 3 days of elevated ANG II levels is
due to 1-receptor
downregulation. To this end, ANG II was administered to rats
1) that were treated with a
-receptor blocker, 2) after
adrenal medullectomy and/or cardiac sympathectomy, and 3) for 3 or 8 days. ANG II caused
both myocyte necrosis and coronary vascular damage after adrenal
medullectomy but not after cardiac sympathectomy. There was a 38 and
55% decrease in -receptor density after 3 and 8 days, respectively,
of ANG II infusion, and an upregulation to control levels 5 days after
a 3-day ANG II infusion was stopped. We conclude that cardiac
sympathetic neuron catecholamines are responsible for ANG Dam and that
the acute nature of this damage is associated with a downregulation of
1-adrenergic receptors.
myocyte necrosis; atenolol; adrenal medullectomy; cardiac sympathectomy; coronary arteriolar damage
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