AJP - Heart Calcium Transients and Cell-Sarcomere
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Heart Circ Physiol 275: H680-H688, 1998;
0363-6135/98 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Keyes, L.
Right arrow Articles by Moore, L. G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Keyes, L.
Right arrow Articles by Moore, L. G.
Vol. 275, Issue 2, H680-H688, August 1998

Effect of K+ATP channel inhibition on total and regional vascular resistance in guinea pig pregnancy

Linda Keyes1,2, David M. Rodman2,3, Douglas Curran-Everett4, Kenneth Morris2, and Lorna G. Moore2,5

1 Yale University School of Medicine, New Haven, Connecticut 06510; 2 Cardiovascular Pulmonary Research Laboratory and Center for Women's Health Research, 3 Division of Pulmonary Sciences and Critical Care Medicine, 4 Department of Pediatrics, University of Colorado Health Sciences Center, Denver, Colorado 80262; and 5 Department of Anthropology, University of Colorado at Denver, Denver, Colorado 80217-3364

Decreased vascular resistance and vasoconstrictor response during pregnancy enables an increase in cardiac output and regional blood flow to the uterine circulation. We sought to determine whether inhibition of vascular smooth muscle ATP-sensitive potassium (K+ATP) channel activity during pregnancy increased systemic and/or regional vascular resistance and resistance response to ANG II. A total of 32 catheterized, awake, pregnant or nonpregnant guinea pigs were treated with either the K+ATP channel inhibitor glibenclamide (3.5 mg/kg) or vehicle (DMSO) (n = 8/group). In nonpregnant and pregnant animals, glibenclamide raised blood pressure and systemic, uterine, and coronary vascular resistance, diminishing cardiac output and organ blood flow. Glibenclamide produced a greater rise in coronary vascular resistance in the pregnant than nonpregnant groups and increased renal and cerebral vascular resistance in the pregnant animals only. ANG II infusion raised blood pressure and systemic and renal vascular resistance and lowered cardiac output and renal blood flow in vehicle-treated animals. Glibenclamide augmented ANG II-induced systemic vasoconstriction in the nonpregnant and pregnant groups and the rise in uteroplacental vascular resistance in the pregnant animals. We concluded that K+ATP channel activity likely modulates systemic, uterine, and coronary vascular resistance and opposes ANG II-induced systemic vasoconstriction in nonpregnant and pregnant guinea pigs. Pregnancy augments K+ATP channel activity in the uterine, coronary, renal, and cerebral vascular beds and the uteroplacental circulation during ANG II infusion. Thus increased K+ATP channel activity appears to influence regional control of vascular resistance during guinea pig pregnancy but cannot account for the characteristic decrease in systemic vascular resistance and ANG II-induced systemic vasoconstrictor response.

nitric oxide; endothelium-derived hyperpolarizing factor; endothelium; glibenclamide; ion channels; ovarian hormones; uterine circulation; vascular smooth muscle; vasodilation


This article has been cited by other articles:


Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
K. Auger, A. Beausejour, M. Brochu, and J. St-Louis
Increased Na+ intake during gestation in rats is associated with enhanced vascular reactivity and alterations of K+ and Ca2+ function
Am J Physiol Heart Circ Physiol, October 1, 2004; 287(4): H1848 - H1856.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
D. R. Bergren
Enhanced lung C-fiber responsiveness in sensitized adult guinea pigs exposed to chronic tobacco smoke
J Appl Physiol, October 1, 2001; 91(4): 1645 - 1654.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
C. R. Rosenfeld, D. N. Cornfield, and T. Roy
Ca2+-activated K+ channels modulate basal and E2{beta}-induced rises in uterine blood flow in ovine pregnancy
Am J Physiol Heart Circ Physiol, July 1, 2001; 281(1): H422 - H431.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
J.J.D. Lucca, A.S.O. Adeagbo, and N.L. Alsip
Oestrous cycle and pregnancy alter the reactivity of the rat uterine vasculature
Hum. Reprod., December 1, 2000; 15(12): 2496 - 2503.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
J.J.D. Lucca, A.S.O. Adeagbo, and N.L. Alsip
Influence of oestrous cycle and pregnancy on the reactivity of the rat mesenteric vascular bed
Hum. Reprod., April 1, 2000; 15(4): 961 - 968.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
C. Cadorette, B. Sicotte, M. Brochu, and J. St-Louis
Effects of potassium channel modulators on myotropic responses of aortic rings of pregnant rats
Am J Physiol Heart Circ Physiol, February 1, 2000; 278(2): H567 - H576.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online