AJP - Heart Calcium Transients and Cell-Sarcomere
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Heart Circ Physiol 275: H697-H702, 1998;
0363-6135/98 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Hsu, E. W.
Right arrow Articles by Forder, J. R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Hsu, E. W.
Right arrow Articles by Forder, J. R.
Vol. 275, Issue 2, H697-H702, August 1998

Delayed reduction of tissue water diffusion after myocardial ischemia

Edward W. Hsu1, Rong Xue1, Alex Holmes1, and John R. Forder2

Departments of 1 Biomedical Engineering and 2 Radiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205-2195

The apparent diffusion coefficient (ADC) of water after regional myocardial ischemia was measured in isolated, perfused rabbit hearts by using magnetic resonance imaging (MRI) techniques. After ligation of the left anterior descending coronary artery, the ADC of the nonperfused region showed a gradual but significant decreasing trend over time, whereas that of the normally perfused myocardium remained constant. Morphological analysis revealed that the ADC decrease reflected the expansion of a subregion of reduced ADC within the nonperfused myocardium. The dynamics of the diffusion change and the morphological progression of the affected tissue suggest that the ADC decrease may be linked to the onset of myocardial infarction, which is known to involve myocyte swelling. The ADC reduction provides a potentially valuable MRI tissue-contrast mechanism for noninvasively determining the viability of the ischemic myocardium and assessing the dynamics of acute myocardial infarction.

magnetic resonance imaging; apparent diffusion coefficient; myocardial infarction


This article has been cited by other articles:


Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
J. Chen, S.-K. Song, W. Liu, M. McLean, J. S. Allen, J. Tan, S. A. Wickline, and X. Yu
Remodeling of cardiac fiber structure after infarction in rats quantified with diffusion tensor MRI
Am J Physiol Heart Circ Physiol, August 7, 2003; 285(3): H946 - H954.
[Abstract] [Full Text] [PDF]

Home page
 JNMHome page
M. Faraggi
The Continuing Story of 201Tl Reverse Redistribution: Reverse Redistribution Is Still Alive, but Is the Myocardium Still Viable?
J. Nucl. Med., May 1, 2002; 43(5): 628 - 631.
[Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
J. R. Forder, J. D. Bui, D. L. Buckley, and S. J. Blackband
MR imaging measurement of compartmental water diffusion in perfused heart slices
Am J Physiol Heart Circ Physiol, September 1, 2001; 281(3): H1280 - H1285.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
D. F. Scollan, A. Holmes, R. Winslow, and J. Forder
Histological validation of myocardial microstructure obtained from diffusion tensor magnetic resonance imaging
Am J Physiol Heart Circ Physiol, December 1, 1998; 275(6): H2308 - H2318.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online