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Am J Physiol Heart Circ Physiol 275: H697-H702, 1998;
0363-6135/98 $5.00
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Vol. 275, Issue 2, H697-H702, August 1998

Delayed reduction of tissue water diffusion after myocardial ischemia

Edward W. Hsu1, Rong Xue1, Alex Holmes1, and John R. Forder2

Departments of 1 Biomedical Engineering and 2 Radiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205-2195

The apparent diffusion coefficient (ADC) of water after regional myocardial ischemia was measured in isolated, perfused rabbit hearts by using magnetic resonance imaging (MRI) techniques. After ligation of the left anterior descending coronary artery, the ADC of the nonperfused region showed a gradual but significant decreasing trend over time, whereas that of the normally perfused myocardium remained constant. Morphological analysis revealed that the ADC decrease reflected the expansion of a subregion of reduced ADC within the nonperfused myocardium. The dynamics of the diffusion change and the morphological progression of the affected tissue suggest that the ADC decrease may be linked to the onset of myocardial infarction, which is known to involve myocyte swelling. The ADC reduction provides a potentially valuable MRI tissue-contrast mechanism for noninvasively determining the viability of the ischemic myocardium and assessing the dynamics of acute myocardial infarction.

magnetic resonance imaging; apparent diffusion coefficient; myocardial infarction


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