AJP - Heart Information on EB 2010
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Heart Circ Physiol 275: H814-H822, 1998;
0363-6135/98 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Li, J.-M.
Right arrow Articles by Brooks, G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Li, J.-M.
Right arrow Articles by Brooks, G.
Vol. 275, Issue 3, H814-H822, September 1998

Role of G1 phase cyclins and cyclin-dependent kinases during cardiomyocyte hypertrophic growth in rats

Jian-Mei Li, Robert A. Poolman, and Gavin Brooks

Cardiovascular Cellular and Molecular Biology, Cardiovascular Research, The Rayne Institute, St. Thomas' Hospital, London SE1 7EH, United Kingdom

Cell cycle regulatory molecules are implicated in cardiomyocyte hypertrophy. We have investigated protein expression of cyclins A, D1-3, and E and cyclin-dependent kinases (CDKs) 2, 4, 5, and 6 in left ventricular (LV) tissues during the development of LV hypertrophy in rats following aortic constriction (AC). Compared with their expression in sham-operated controls (SH), expression of cyclins D2 and D3 and of CDK4 and CDK6 increased significantly from day 3 to day 21 after AC concomitant with increased LV mass. However, no significant difference was observed for CDK2 or CDK5. Cyclins A, D1, and E were undetectable. In vitro kinase activities of CDK4 and CDK6 increased ~70% from day 7 to day 14 in AC myocytes compared with SH myocytes (P < 0.03). Fluorescence-activated cell sorter analysis revealed a G0/G1 to G2/M phase progression in AC myocyte nuclei (22.0 ± 1.1% in G2/M) by day 7 postoperation compared with progression in SH myocyte nuclei (14.0 ± 0.8% in G2/M; P < 0.01). Thus an upregulation of certain cell cycle regulators is associated with cardiomyocyte hypertrophy.

cell cycle; heart; myocyte; pressure overload


This article has been cited by other articles:


Home page
 Physiol. Rev.Home page
P. Ahuja, P. Sdek, and W. R. MacLellan
Cardiac Myocyte Cell Cycle Control in Development, Disease, and Regeneration
Physiol Rev, April 1, 2007; 87(2): 521 - 544.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
C. Indolfi, E. Di Lorenzo, C. Perrino, A. M. Stingone, A. Curcio, D. Torella, A. Cittadini, L. Cardone, C. Coppola, L. Cavuto, et al.
Hydroxymethylglutaryl Coenzyme A Reductase Inhibitor Simvastatin Prevents Cardiac Hypertrophy Induced by Pressure Overload and Inhibits p21ras Activation
Circulation, October 15, 2002; 106(16): 2118 - 2124.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
H.-S. Liao, P. M. Kang, H. Nagashima, N. Yamasaki, A. Usheva, B. Ding, B. H. Lorell, and S. Izumo
Cardiac-Specific Overexpression of Cyclin-Dependent Kinase 2 Increases Smaller Mononuclear Cardiomyocytes
Circ. Res., March 2, 2001; 88(4): 443 - 450.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
K. B. S. Pasumarthi, H. Nakajima, H. O. Nakajima, S. Jing, and L. J. Field
Enhanced Cardiomyocyte DNA Synthesis During Myocardial Hypertrophy in Mice Expressing a Modified TSC2 Transgene
Circ. Res., May 26, 2000; 86(10): 1069 - 1077.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
R. A. Poolman, J.-M. Li, B. Durand, and G. Brooks
Altered Expression of Cell Cycle Proteins and Prolonged Duration of Cardiac Myocyte Hyperplasia in p27KIP1 Knockout Mice
Circ. Res., July 23, 1999; 85(2): 117 - 127.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
G. Xiao, S. Mao, G. Baumgarten, J. Serrano, M. C. Jordan, K. P. Roos, M. C. Fishbein, and W. R. MacLellan
Inducible Activation of c-Myc in Adult Myocardium In Vivo Provokes Cardiac Myocyte Hypertrophy and Reactivation of DNA Synthesis
Circ. Res., December 7, 2001; 89(12): 1122 - 1129.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online