|
|
||||||||
1 Program in Molecular and
Cellular Cardiology,
The aim of the present study was to test the hypothesis that bradykinin-stimulated release of nitric oxide (NO) and/or prostacyclin from endothelium blocks myocyte hypertrophy in vitro. Angiotensin II increased [3H]phenylalanine incorporation by 21 ± 2% in myocytes cocultured with endothelial cells; this was abolished by bradykinin in the presence of endothelial cells. Bradykinin increased cytosolic concentrations of cGMP by 29 ± 4% in myocytes cocultured with endothelial cells. This was abolished by inhibition of NO synthase and by a cyclooxygenase inhibitor. Angiotensin II also increased [3H]phenylalanine incorporation by 28 ± 3% in myocytes cultured in the absence of endothelial cells. This effect of angiotensin II in monoculture was abolished by donors of NO but not by bradykinin. Neither the stable analog of prostacyclin (iloprost) nor the prostacyclin second messanger analog 8-bromo-cAMP (8-BrcAMP) blocked the effect of angiotensin II. Furthermore, 8-BrcAMP and iloprost individually increased [3H]phenylalanine incorporation. The antihypertrophic effects of bradykinin are critically dependent on endothelium-derived NO.
angiotensin converting-enzyme inhibitors; bradykinin; prostacyclin; endothelium
This article has been cited by other articles:
![]() |
M. C. de Waard, J. van der Velden, N. M. Boontje, D. H. W. Dekkers, R. van Haperen, D. W. D. Kuster, J. M. J. Lamers, R. de Crom, and D. J. Duncker Detrimental effect of combined exercise training and eNOS overexpression on cardiac function after myocardial infarction Am J Physiol Heart Circ Physiol, May 1, 2009; 296(5): H1513 - H1523. [Abstract] [Full Text] [PDF] |
||||
![]() |
H. D. Xiao, S. Fuchs, E. A. Bernstein, P. Li, D. J. Campbell, and K. E. Bernstein Mice expressing ACE only in the heart show that increased cardiac angiotensin II is not associated with cardiac hypertrophy Am J Physiol Heart Circ Physiol, February 1, 2008; 294(2): H659 - H667. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. Allard, M. Buleon, E. Cellier, I. Renaud, C. Pecher, F. Praddaude, M. Conti, I. Tack, and J.-P. Girolami ACE inhibitor reduces growth factor receptor expression and signaling but also albuminuria through B2-kinin glomerular receptor activation in diabetic rats Am J Physiol Renal Physiol, October 1, 2007; 293(4): F1083 - F1092. [Abstract] [Full Text] [PDF] |
||||
![]() |
E. S. Buys, M. J. Raher, S. L. Blake, T. G. Neilan, A. R. Graveline, J. J. Passeri, M. Llano, T. M. Perez-Sanz, F. Ichinose, S. Janssens, et al. Cardiomyocyte-restricted restoration of nitric oxide synthase 3 attenuates left ventricular remodeling after chronic pressure overload Am J Physiol Heart Circ Physiol, July 1, 2007; 293(1): H620 - H627. [Abstract] [Full Text] [PDF] |
||||
![]() |
D. Bell, Y.-Y. Zhao, E. J. Kelso, E. M. McHenry, L. M. Rush, V. M. Lamont, D. P. Nicholls, and B. J. McDermott Upregulation of adrenomedullin and its receptor components during cardiomyocyte hypertrophy induced by chronic inhibition of nitric oxide synthesis in rats Am J Physiol Heart Circ Physiol, February 1, 2006; 290(2): H904 - H914. [Abstract] [Full Text] [PDF] |
||||
![]() |
C. Rugale, M. Cordaillat, A. Mimran, and B. Jover Prevention and Reversal by Enalapril of Target Organ Damage in Angiotensin II Hypertension Journal of Renin-Angiotensin-Aldosterone System, September 1, 2005; 6(3): 154 - 160. [Abstract] [PDF] |
||||
![]() |
R. H. Ritchie, A. C. Rosenkranz, L. P. Huynh, T. Stephenson, D. M. Kaye, and G. J. Dusting Activation of IP prostanoid receptors prevents cardiomyocyte hypertrophy via cAMP-dependent signaling Am J Physiol Heart Circ Physiol, September 1, 2004; 287(3): H1179 - H1185. [Abstract] [Full Text] [PDF] |
||||
![]() |
F. Ichinose, K. D. Bloch, J. C. Wu, R. Hataishi, H. T. Aretz, M. H. Picard, and M. Scherrer-Crosbie Pressure overload-induced LV hypertrophy and dysfunction in mice are exacerbated by congenital NOS3 deficiency Am J Physiol Heart Circ Physiol, March 1, 2004; 286(3): H1070 - H1075. [Abstract] [Full Text] [PDF] |
||||
![]() |
G. Bledsoe, L. Chao, and J. Chao Kallikrein gene delivery attenuates cardiac remodeling and promotes neovascularization in spontaneously hypertensive rats Am J Physiol Heart Circ Physiol, October 1, 2003; 285(4): H1479 - H1488. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. H. Lombard, F. A. Sylvester, S. A. Phillips, and J. C. Frisbee High-salt diet impairs vascular relaxation mechanisms in rat middle cerebral arteries Am J Physiol Heart Circ Physiol, April 1, 2003; 284(4): H1124 - H1133. [Abstract] [Full Text] [PDF] |
||||
![]() |
D. L. Brutsaert Cardiac Endothelial-Myocardial Signaling: Its Role in Cardiac Growth, Contractile Performance, and Rhythmicity Physiol Rev, January 1, 2003; 83(1): 59 - 115. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. C. Frisbee, F. A. Sylvester, and J. H. Lombard High-salt diet impairs hypoxia-induced cAMP production and hyperpolarization in rat skeletal muscle arteries Am J Physiol Heart Circ Physiol, October 1, 2001; 281(4): H1808 - H1815. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. Scherrer-Crosbie, R. Ullrich, K. D. Bloch, H. Nakajima, B. Nasseri, H. T. Aretz, M. L. Lindsey, A.-C. Vancon, P. L. Huang, R. T. Lee, et al. Endothelial Nitric Oxide Synthase Limits Left Ventricular Remodeling After Myocardial Infarction in Mice Circulation, September 11, 2001; 104(11): 1286 - 1291. [Abstract] [Full Text] [PDF] |
||||
![]() |
L. J. Murphey, D. L. Hachey, J. A. Oates, J. D. Morrow, and N. J. Brown Metabolism of Bradykinin In Vivo in Humans: Identification of BK1-5 as a Stable Plasma Peptide Metabolite J. Pharmacol. Exp. Ther., July 1, 2000; 294(1): 263 - 269. [Abstract] [Full Text] |
||||
![]() |
S. Kim and H. Iwao Molecular and Cellular Mechanisms of Angiotensin II-Mediated Cardiovascular and Renal Diseases Pharmacol. Rev., March 1, 2000; 52(1): 11 - 34. [Abstract] [Full Text] [PDF] |
||||
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |