AJP - Heart Calcium Transients and Cell-Sarcomere
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Am J Physiol Heart Circ Physiol 275: H1455-H1461, 1998;
0363-6135/98 $5.00
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Vol. 275, Issue 4, H1455-H1461, October 1998

A nonlinear explanation of aging-induced changes in heartbeat dynamics

A. Giuliani1, G. Piccirillo2, V. Marigliano2, and A. Colosimo3

1 Istituto Superiore di Sanità, Laboratory of Comparative Toxicology and Ecotoxicology and 2 Prima Clinica Medica Policlinico Umberto I, 00161 Rome; and 3 Dipartimento di Scienze Biochimiche, Università di Roma La Sapienza, 00185 Rome, Italy

The possibility of computing a cardiac age on the basis of spectral analysis of healthy individual tachograms was confirmed and facilitated by the use of a nonlinear technique: recurrence quantification analysis. The age of 112 subjects was predicted by this technique in terms of a progressive increase in the deterministic character of the heartbeat. This result confirms the "random-walk" character of the heartbeat as predicted by the terminal dynamics paradigm, thus allowing for a simple and comprehensive model of the effect of aging on cardiac dynamics: as age progresses, heart rate dynamics become increasingly predictable (constrained) on a beat-to-beat basis. This implies a basically stochastic nature of heart rate dynamics, probably reflecting the continuous adjustments to an unpredictable internal environment.

recurrence quantification analysis; nonlinear dynamics; heart rate variability; terminal dynamics


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