AJP - Heart Watch the video to learn how APS reaches out to developing nations.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Heart Circ Physiol 275: H1503-H1512, 1998;
0363-6135/98 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Beaufort-Krol, G. C. M.
Right arrow Articles by Kuipers, J. R. G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Beaufort-Krol, G. C. M.
Right arrow Articles by Kuipers, J. R. G.
Vol. 275, Issue 5, H1503-H1512, November 1998

Increased myocardial lactate oxidation in lambs with aortopulmonary shunts at rest and during exercise

Gertie C. M. Beaufort-Krol, Janny Takens, Marieke C. Molenkamp, Gioia B. Smid, Koos J. Meuzelaar, Willem G. Zijlstra, and Jaap R. G. Kuipers

Division of Pediatric Cardiology and Thoracic Surgery, Beatrix Children's Hospital, University of Groningen, 9700 RB Groningen; and Groningen Utrecht Institute for Drug Exploration, 9713 BZ Groningen, The Netherlands

Free fatty acids are the major fuels for the myocardium, but during a higher load carbohydrates are preferred. Previously, we demonstrated that myocardial net lactate uptake was higher in lambs with aortopulmonary shunts than in control lambs. To determine whether this was caused by an increased lactate uptake and oxidation or by a decreased lactate release, we studied myocardial lactate and glucose metabolism with 13C-labeled substrates in 36 lambs in a fasting, conscious state. The lambs were assigned to two groups: a resting group consisting of 8 shunt and 9 control lambs, and an exercise group (50% of peak O2 consumption) consisting of 9 shunt and 10 control lambs. Myocardial lactate oxidation was higher in shunt than in control lambs (mean ± SE, rest: 10.33 ± 2.61 vs. 0.17 ± 0.82, exercise: 38.05 ± 8.87 vs. 16.89 ± 4.78 µmol · min-1 · 100 g-1; P < 0.05). There was no difference in myocardial lactate release between shunt and control lambs. Oxidation of exogenous glucose, which was approximately zero at rest, increased during exercise in shunt and control lambs. The contribution of glucose and lactate to myocardial oxidative metabolism increased during exercise compared with at rest in both shunt and control lambs. We conclude that myocardial lactate oxidation is higher in shunt than in control lambs, both at rest and during exercise, and that the contribution of carbohydrates in myocardial oxidative metabolism in shunt lambs is higher than in control lambs. Thus it appears that this higher contribution of carbohydrates occurs not only in the case of pressure-overloaded hearts but also in myocardial hypertrophy due to volume overloading.

carbon-13-labeled substrates; congenital heart disease; left-to-right shunt; glucose; metabolism


This article has been cited by other articles:


Home page
 JNMHome page
P. Herrero, Z. Kisrieva-Ware, C. S. Dence, B. Patterson, A. R. Coggan, D.-H. Han, Y. Ishii, P. Eisenbeis, and R. J. Gropler
PET Measurements of Myocardial Glucose Metabolism with 1-11C-Glucose and Kinetic Modeling
J. Nucl. Med., June 1, 2007; 48(6): 955 - 964.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
R. K. Evans, D. D. Schwartz, and L. B. Gladden
Effect of myocardial volume overload and heart failure on lactate transport into isolated cardiac myocytes
J Appl Physiol, March 1, 2003; 94(3): 1169 - 1176.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
B. Bartelds, H. Knoester, G. B. Smid, J. Takens, G. H. Visser, L. Penninga, F. R. van der Leij, G. C. M. Beaufort-Krol, W. G. Zijlstra, H. S. A. Heymans, et al.
Perinatal Changes in Myocardial Metabolism in Lambs
Circulation, August 22, 2000; 102(8): 926 - 931.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
G. C. M. Beaufort-Krol, W. G. Zijlstra, J. Takens, M. C. Molenkamp, K. J. Meuzelaar, G. B. Smid, and J. R. G. Kuipers
Lactate kinetics at rest and during exercise in lambs with aortopulmonary shunts
J Appl Physiol, March 1, 1999; 86(3): 832 - 839.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online