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Am J Physiol Heart Circ Physiol 275: H1663-H1672, 1998;
0363-6135/98 $5.00
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Vol. 275, Issue 5, H1663-H1672, November 1998

Role of adenosine in the regulation of coronary blood flow in swine at rest and during treadmill exercise

Dirk J. Duncker, René Stubenitsky, and Pieter D. Verdouw

Experimental Cardiology, Thoraxcenter, Cardiovascular Research Institute COEUR, Erasmus University Rotterdam, 3000 DR Rotterdam, The Netherlands

A pivotal role for adenosine in the regulation of coronary blood flow is still controversial. Consequently, we investigated its role in the regulation of coronary vasomotor tone in swine at rest and during graded treadmill exercise. During exercise, myocardial O2 consumption increased from 167 ± 18 µmol/min at rest to 399 ± 27 µmol/min at 5 km/h (P <=  0.05), which was paralleled by an increase in O2 delivery, so that myocardial O2 extraction (76 ± 1 and 78 ± 1% at rest and 5 km/h, respectively) and coronary venous PO2 (24.5 ± 1.0 and 22.8 ± 0.3 mmHg at rest and 5 km/h, respectively) remained unchanged. After adenosine receptor blockade with 8-phenyltheophylline (5 mg/kg iv), the relation between myocardial O2 consumption and coronary vascular resistance was shifted toward higher resistance, whereas myocardial O2 extraction rose to 81 ± 1 and 83 ± 1% at rest and 5 km/h and coronary venous PO2 fell to 19.2 ± 0.8 and 18.9 ± 0.8 mmHg at rest and 5 km/h, respectively (all P <=  0.05). Thus, although adenosine is not mandatory for the exercise-induced coronary vasodilation, it exerts a vasodilator influence on the coronary resistance vessels in swine at rest and during exercise.

coronary circulation; myocardial oxygen extraction; myocardial oxygen consumption; pulmonary circulation; systemic circulation


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