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Division of Cardiovascular Medicine and Department of Pharmacology, University of California, Davis, California, 95616
We sought to determine whether glutamate
acting at both
N-methyl-D-aspartate
(NMDA) and non-NMDA receptors transmits area postrema (AP) excitatory
inputs to nucleus tractus solitarii (NTS) neurons in the aortic
baroreceptor or vagal afferent pathways in vivo. In
-chloralose-anesthetized rabbits, we recorded extracellular NTS
neuronal responses to low-frequency aortic depressor nerve (ADN), vagus
nerve, and AP stimulation and to iontophoresis of -amino-3-hydroxy-5-methylisoxazole-4-propionic acid and NMDA during
control, iontophoresis of
2,3-dihdroxy-6-nitro-7-sulfamoylbenzo(f)quinoxaline (NBQX),
DL-2-amino-5-phosphonovaleric
acid (AP5), or both, and recovery conditions. In neurons receiving AP
and ADN inputs, NBQX attenuated AP- and ADN-evoked responses by 46 (P = 0.0206) and 49%
(P = 0.0042). AP5 attenuated AP- and
ADN-evoked responses by 39 (P = 0.0270) and 40% (P = 0.0157). NBQX + AP5 attenuated AP- and ADN-evoked responses by 74 (P = 0.0040) and 75%
(P = 0.0028). In neurons receiving AP
and vagal inputs, AP transmission was attenuated by 58, 60, and 98%;
vagal transmission was attenuated by 62, 35, and 83% during NBQX, AP5,
and both antagonists, respectively. These data suggest that both
non-NMDA and NMDA receptors transmit AP input to NTS neurons in aortic
baroreceptor or vagal afferent pathways.
neurotransmitter; aortic depressor nerve; vagus nerve
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